1,2-Benzisoxazole - >96.0%(GC), high purity , CAS No.271-95-4

  • ≥96%(GC)
Item Number
B151955
Grouped product items
SKUSizeAvailabilityPrice Qty
B151955-200mg
200mg
In stock
$9.90
B151955-1g
1g
In stock
$21.90
B151955-5g
5g
In stock
$82.90
B151955-25g
25g
In stock
$319.90

Basic Description

SynonymsJ-016689 | Q791818 | Z220335556 | DTXSID20181567 | EN300-25961 | G9L6B3W684 | 1,2-benzoisoxazole | CHEBI:51554 | Benzo[d]isoxazole | A818951 | benzisoxazole | SCHEMBL2213595 | THUJAPLICIN, BETA | Indoxazene | FT-0627231 | 1,2-benzoxazole | CS-0155959 | 1,
Specifications & Purity≥96%(GC)
Storage TempStore at 2-8°C,Protected from light,Argon charged
Shipped InWet ice
Product Description

1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase.

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1,2-benzoxazole
INCHI InChI=1S/C7H5NO/c1-2-4-7-6(3-1)5-8-9-7/h1-5H
InChi Key KTZQTRPPVKQPFO-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=NO2
Isomeric SMILES C1=CC=C2C(=C1)C=NO2
WGK Germany 3
PubChem CID 71073
Molecular Weight 119.12
Beilstein 2154

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
I2207327Certificate of AnalysisJul 03, 2022 B151955
I2207328Certificate of AnalysisJul 03, 2022 B151955
I2207329Certificate of AnalysisJul 03, 2022 B151955
I2207331Certificate of AnalysisJul 03, 2022 B151955

Chemical and Physical Properties

SolubilitySoluble in water. 4.1 mg/mL in water at 25°C
SensitivityLight & heat & air sensitive
Refractive Index1.562
Flash Point(°F)186.8 °F
Flash Point(°C)86°C
Boil Point(°C)90-92°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

References

1. Koon HW, Shih D, Karagiannides I, Zhao D, Fazelbhoy Z, Hing T, Xu H, Lu B, Gerard N, Pothoulakis C.  (2010)  Substance P modulates colitis-associated fibrosis..  Am J Pathol,  177  (5): (2300-9).  [PMID:20889569] [10.1021/op500134e]
2. D H Peters,E M Sorkin.  (1993-05-01)  Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy..  Drugs,  45  ((5)): (760-787).  [PMID:7686468]
3. Fu-Jun Liu,Aaron Barchowsky,Patricia L Opresko.  (2009-06-03)  The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage..  Toxicological sciences : an official journal of the Society of Toxicology,  110  ((2)): (307-318).  [PMID:19487340]
4. Nigel Greene,Lilia Fisk,Russell T Naven,Reine R Note,Mukesh L Patel,Dennis J Pelletier.  (2010-06-18)  Developing structure-activity relationships for the prediction of hepatotoxicity..  Chemical research in toxicology,  23  ((7)): (1215-1222).  [PMID:20553011]
5. Sean Ekins,Antony J Williams,Jinghai J Xu.  (2010-09-17)  A predictive ligand-based Bayesian model for human drug-induced liver injury..  Drug metabolism and disposition: the biological fate of chemicals,  38  ((12)): (2302-2308).  [PMID:20843939]
6. Hon Wai Koon,David Q Shih,Tressia C Hing,Jeremy Chen,Samantha Ho,Dezheng Zhao,Stephan R Targan,Charalabos Pothoulakis.  (2011-09-29)  Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells..  The American journal of pathology,  179  ((5)): (2315-2326).  [PMID:21945803]
7. Dallas R Donohoe,Darcy Holley,Leonard B Collins,Stephanie A Montgomery,Alan C Whitmore,Andrew Hillhouse,Kaitlin P Curry,Sarah W Renner,Alicia Greenwalt,Elizabeth P Ryan,Virginia Godfrey,Mark T Heise,Deborah S Threadgill,Anna Han,James A Swenberg,David W Threadgill,Scott J Bultman.  (2014-10-01)  A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner..  Cancer discovery,  ((12)): (1387-1397).  [PMID:25266735]
8. Min Bao,Chengtuo Niu,Xin Xu,Feiyun Zheng,Chunfeng Liu,Jinjing Wang,Qi Li.  (2019-06-25)  Identification, soluble expression, and characterization of a novel endo-inulinase from Lipomyces starkeyi NRRL Y-11557..  International journal of biological macromolecules,  137  (537-544).  [PMID:31233793]
9. W Gristwood,K Wilson.  (1988-08-01)  Kinetics of some benzothiazoles, benzoxazoles, and quinolines as substrates and inhibitors of rabbit liver aldehyde oxidase..  Xenobiotica; the fate of foreign compounds in biological systems,  18  ((8)): (949-954).  [PMID:3188574]
10. Hon-Wai Koon,Dezheng Zhao,Hua Xu,Collin Bowe,Alan Moss,Mary P Moyer,Charalabos Pothoulakis.  (2008-07-05)  Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis..  The American journal of pathology,  173  ((2)): (400-410).  [PMID:18599605]
11. Avneet Kaur,Dharam P Pathak,Vidushi Sharma,Sharad Wakode.  (2018-05-10)  Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents..  Archiv der Pharmazie,  351  ((6)): (e1800008-e1800008).  [PMID:29741797]

Solution Calculators