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1-[2-chloro-4-ethoxy-5-(morpholin-4-yl)benzoyl]-3-{6-[(4-methylpiperazin-1-yl)methyl]-1,3-benzothiazol-2-yl}urea , CAS No.C609088, Agonist of HCA 1 receptor

Moligand™

PubChem CID: 154699458

Item Number

C609088

Grouped product items
SKU	Size	Availability	Price	Qty
C609088-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C609088-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

HCA1 receptor Agonist

Synonyms

AZ2;compound 2

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of HCA 1 receptor

Associated Targets

HCAR2 Tclin Hydroxycarboxylic acid receptor 2 0 Activities

Discover Target: HCAR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GHSR Tclin Growth hormone secretagogue receptor type 1 0 Activities

Discover Target: GHSR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCAR1 Tchem Hydroxycarboxylic acid receptor 1 1 Activities

Discover Target: HCAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[2-chloro-4-ethoxy-5-(morpholin-4-yl)benzoyl]-3-{6-[(4-methylpiperazin-1-yl)methyl]-1,3-benzothiazol-2-yl}urea
INCHI	InChI=1S/C27H33ClN6O4S/c1-3-38-23-16-20(28)19(15-22(23)34-10-12-37-13-11-34)25(35)30-26(36)31-27-29-21-5-4-18(14-24(21)39-27)17-33-8-6-32(2)7-9-33/h4-5,14-16H,3,6-13,17H2,1-2H3,(H2,29,30,31,35,36)
InChi Key	NNVMPPRFBOTMMO-UHFFFAOYSA-N
Canonical SMILES	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C
Isomeric SMILES	CCOC1=C(C=C(C(=C1)Cl)C(=O)NC(=O)NC2=NC3=C(S2)C=C(C=C3)CN4CCN(CC4)C)N5CCOCC5
PubChem CID	154699458

GPCRdb Ligand

compound 2 [PMID: 31932225]

PubChem CID

154699458

References

1. Wallenius K, Thalén P, Björkman JA, Johannesson P, Wiseman J, Böttcher G, Fjellström O, Oakes ND. (2017) Involvement of the metabolic sensor GPR81 in cardiovascular control.. JCI Insight, 2 (19): (589-97). [PMID:28978803]
2. Davidsson Ö, Nilsson K, Brånalt J, Andersson T, Berggren K, Chen Y, Fjellström O, Gradén H, Gustafsson L, Hermansson NO et al.. (2020) Identification of novel GPR81 agonist lead series for target biology evaluation.. Bioorg Med Chem Lett, 30 (4): (126953). [PMID:31932225]

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1-[2-chloro-4-ethoxy-5-(morpholin-4-yl)benzoyl]-3-{6-[(4-methylpiperazin-1-yl)methyl]-1,3-benzothiazol-2-yl}urea , CAS No.C609088, Agonist of HCA 1 receptor

Basic Description

Associated Targets

HCAR2 Tclin Hydroxycarboxylic acid receptor 2 0 Activities

GHSR Tclin Growth hormone secretagogue receptor type 1 0 Activities

HCAR1 Tchem Hydroxycarboxylic acid receptor 1 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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Dilution Calculator

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