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1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea , CAS No.D609099, Inhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

  • Moligand™
Item Number
D609099
Grouped product items
SKUSizeAvailabilityPrice Qty
D609099-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609099-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonymscompound 30
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

Associated Targets

TESK1 Tchem Dual specificity testis-specific protein kinase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LIMK1 Tchem LIM domain kinase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LIMK2 Tchem LIM domain kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TESK2 Tchem Dual specificity testis-specific protein kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea
INCHI InChI=1S/C26H29N7O2S/c1-6-17(7-2)35-18-10-15(3)23(16(4)11-18)20-12-19(22-14-30-26(36-22)33-25(34)27-5)31-24(32-20)21-13-28-8-9-29-21/h8-14,17H,6-7H2,1-5H3,(H2,27,30,33,34)
InChi Key RYXLLTGGHCFCFK-UHFFFAOYSA-N
Canonical SMILES CNC(=O)Nc1ncc(s1)c1nc(nc(c1)c1c(C)cc(cc1C)OC(CC)CC)c1nccnc1
Isomeric SMILES CCC(CC)OC1=CC(=C(C(=C1)C)C2=NC(=NC(=C2)C3=CN=C(S3)NC(=O)NC)C4=NC=CN=C4)C
PubChem CID 58688690

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Related Documents

References

1. Røsok O, Pedeutour F, Ree AH, Aasheim HC.  (1999)  Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis..  Genomics,  61  (1): (44-54).  [PMID:10512679]
2. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K.  (2001)  Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells..  J Biol Chem,  276  (33): (31449-58).  [PMID:11418599]
3. Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM.  (2008)  Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton..  Mol Biol Cell,  19  (4): (1391-403).  [PMID:18216281]
4. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al..  (2012)  Modulation of cofilin phosphorylation by inhibition of the Lim family kinases..  Bioorg Med Chem Lett,  22  (18): (5995-8).  [PMID:22902653]
5. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P.  (1998)  Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase..  Nature,  393  (6687): (805-9).  [PMID:9655397]
6. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K.  (1998)  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization..  Nature,  393  (6687): (809-12).  [PMID:9655398]

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