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1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea , CAS No.E609104, Inhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

  • Moligand™
Item Number
E609104
Grouped product items
SKUSizeAvailabilityPrice Qty
E609104-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$600.90
E609104-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonymscompound 31
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

Associated Targets

DDR1 Tchem Epithelial discoidin domain-containing receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK36 Tbio Serine/threonine-protein kinase 36 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TESK1 Tchem Dual specificity testis-specific protein kinase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TGFBR1 Tchem TGF-beta receptor type-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TEK Tclin Angiopoietin-1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LIMK1 Tchem LIM domain kinase 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LIMK2 Tchem LIM domain kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACVR1B Tchem Activin receptor type-1B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TESK2 Tchem Dual specificity testis-specific protein kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

INCHI InChI=1S/C23H23N7O2S/c1-5-25-22(31)30-23-27-12-19(33-23)16-10-17(20-13(2)8-15(32-4)9-14(20)3)29-21(28-16)18-11-24-6-7-26-18/h6-12H,5H2,1-4H3,(H2,25,27,30,31)
InChi Key WUCYRTXFXRZKSV-UHFFFAOYSA-N
Canonical SMILES CCNC(=O)Nc1ncc(s1)c1cc(nc(n1)c1cnccn1)c1c(C)cc(cc1C)OC
Isomeric SMILES CCNC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4C)OC)C
PubChem CID 46192505

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Røsok O, Pedeutour F, Ree AH, Aasheim HC.  (1999)  Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis..  Genomics,  61  (1): (44-54).  [PMID:10512679]
2. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K.  (2001)  Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells..  J Biol Chem,  276  (33): (31449-58).  [PMID:11418599]
3. Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM.  (2008)  Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton..  Mol Biol Cell,  19  (4): (1391-403).  [PMID:18216281]
4. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al..  (2012)  Modulation of cofilin phosphorylation by inhibition of the Lim family kinases..  Bioorg Med Chem Lett,  22  (18): (5995-8).  [PMID:22902653]
5. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P.  (1998)  Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase..  Nature,  393  (6687): (805-9).  [PMID:9655397]
6. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K.  (1998)  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization..  Nature,  393  (6687): (809-12).  [PMID:9655398]

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