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Applications
Targets
G protein-coupled receptors (GPCRs)
Metabotropic glutamate receptors
1-methyl-2-{[(1R,5S,6S)-6-({[5-(trifluoromethyl)pyridin-2-yl]methoxy}methyl)-3-azabicyclo[3.1.0]hexan-3-yl]methyl}-1H-1,3-benzodiazole , CAS No.M608718, Allosteric modulator of mGlu 2 receptor

1-methyl-2-{[(1R,5S,6S)-6-({[5-(trifluoromethyl)pyridin-2-yl]methoxy}methyl)-3-azabicyclo[3.1.0]hexan-3-yl]methyl}-1H-1,3-benzodiazole , CAS No.M608718, Allosteric modulator of mGlu 2 receptor

Item Number

M608718

Grouped product items
SKU	Size	Availability	Price	Qty
M608718-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M608718-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 14c
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 2 receptor

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1-methyl-2-{[(1R,5S,6S)-6-({[5-(trifluoromethyl)pyridin-2-yl]methoxy}methyl)-3-azabicyclo[3.1.0]hexan-3-yl]methyl}-1H-1,3-benzodiazole
INCHI	InChI=1S/C22H23F3N4O/c1-28-20-5-3-2-4-19(20)27-21(28)11-29-9-16-17(10-29)18(16)13-30-12-15-7-6-14(8-26-15)22(23,24)25/h2-8,16-18H,9-13H2,1H3/t16-,17+,18+
InChi Key	YKYWUHHZZRBGMG-PIIMJCKOSA-N
Canonical SMILES	Cn1c(CN2C[C@@H]3[C@H](C2)[C@H]3COCc2ccc(cn2)C(F)(F)F)nc2c1cccc2
Isomeric SMILES	CN1C2=CC=CC=C2N=C1CN3C[C@@H]4[C@H](C3)C4COCC5=NC=C(C=C5)C(F)(F)F
PubChem CID	73755201

PubChem CID	73755201
GPCRdb Ligand	compound 14c [PMID: 18812259]

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