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1-Methylhistamine dihydrochloride - 98%, high purity , CAS No.6481-48-7, Agonist of H 3 receptor;Agonist of H 4 receptor

Moligand™
≥98%

CAS#: 6481-48-7
Formula: C₆H₁₁N₃ · 2HCl
Molecular Weight: 198.09
PubChem CID: 11957601

Item Number

N611084

Grouped product items
SKU	Size	Availability	Price
N611084-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90
N611084-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,599.90
N611084-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,999.90
N611084-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$512.90

View related series

Endogenous Metabolite H3 receptor Agonist H4 receptor Agonist

Basic Description

Synonyms	Tele-methylhistamine \| N-methylhistamine \| 1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s dis
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of H 3 receptor;Agonist of H 4 receptor
Product Description	1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH4 Tchem Histamine H4 receptor 2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(1-methylimidazol-4-yl)ethanamine;dihydrochloride
INCHI	InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChi Key	AGXVEALMQHTMSW-UHFFFAOYSA-N
Canonical SMILES	CN1C=C(N=C1)CCN.Cl.Cl
Isomeric SMILES	CN1C=C(N=C1)CCN.Cl.Cl
Alternate CAS	501-75-7(free base)
PubChem CID	11957601
Molecular Weight	198.09

PubChem CID

3614

ChEBI

CHEBI:29009

CAS Registry No.

501-75-7

Wikipedia

Alpha-Methylhistamine

ChEMBL Ligand

CHEMBL507

GPCRdb Ligand

N-methylhistamine

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
F2418133	Certificate of Analysis	Mar 01, 2024	N611084
F2418134	Certificate of Analysis	Mar 01, 2024	N611084
F2418135	Certificate of Analysis	Mar 01, 2024	N611084
F2418206	Certificate of Analysis	Mar 01, 2024	N611084
F2418207	Certificate of Analysis	Mar 01, 2024	N611084
F2418208	Certificate of Analysis	Mar 01, 2024	N611084
F2418209	Certificate of Analysis	Mar 01, 2024	N611084
F2418211	Certificate of Analysis	Mar 01, 2024	N611084

Solubility

Solubility：DMSO

Sensitivity

Moisture sensitive

Melt Point(°C)

202-203° C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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