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CAMK:Calcium/calmodulin-dependent protein kinases
10-DEBC hydrochloride - ≥99 %, high purity , CAS No.201788-90-1, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

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10-DEBC hydrochloride - ≥99 %, high purity , CAS No.201788-90-1, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

≥99%

CAS#: 201788-90-1
Formula: C₂₀H₂₅ClN₂O・HCl
Molecular Weight: 381.34
PubChem CID: 16760284

Item Number

D335507

Grouped product items
SKU	Size	Availability	Price	Qty
D335507-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$122.90
D335507-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$520.90

a selective inhibitor of Akt/PKB

View related series

Pim-1 proto-oncogene，serine/threonine kinase Inhibitor

Basic Description

Synonyms	10-DEBC HYDROCHLORIDE\|Akt Inhibitor X\|925681-41-0\|201788-90-1\|10-DEBC (hydrochloride)\|10-DEBCHYDROCHLORIDE\|Akt Inhibitor (10-NCP)\|CCG-206734\|4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride\|4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylb
Specifications & Purity	≥99 %
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase
Product Description	Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kin

Associated Targets

PIM1 Tchem Serine/threonine-protein kinase pim-1 1 Activities

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride
INCHI	InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
InChi Key	SVKSJUIYYCQZEC-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
Isomeric SMILES	CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
PubChem CID	16760284
Molecular Weight	381.34

Database links

PubChem CID	10521421
ChEMBL Ligand	CHEMBL1398474
CAS Registry No.	201788-90-1
RCSB PDB Ligand	RTX

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in water (1 mg/ml), DMSO (100 mM), and methanol.
Refractive Index	n20D1.57 (Predicted)

References

1. Thimmaiah KN, Easton JB, Germain GS, Morton CL, Kamath S, Buolamwini JK, Houghton PJ. (2005) Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.. J Biol Chem, 280 (36): (31924-35). [PMID:16009706]

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