Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor
Product Description
11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1 . Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC|50|of 0.25 μM. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The K|i|values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.
