12(S)-HETE - ~100μg/mL in ethanol，98%, high purity , CAS No.54397-83-0, Agonist of BLT 2 receptor;Agonist of GPR31

Item Number

H342782

• Synonyms: 12(S)-HETE|54397-83-0|12S-HETE|CHEBI:34146|(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid|12-Hydroxyeicosatetraenoic acid|12(S)-Hydroxyeicosatetraenoic acid|WG8M7C9ALT|12-Hete|12-Hete, (S)-|12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic aci
• Specifications & Purity: Moligand™, ≥98%, 100μg/mL in ethanol
• Biochemical and Physiological Mechanisms: 12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activit
• Storage Temp: Protected from light,Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST
• Mechanism of action: Agonist of BLT 2 receptor;Agonist of GPR31

Product Description

12(S)-HETE is an arachidonic acid metabolite synthesized in the 12-lipoxygenase pathway in platelets and macrophages. Studies suggest that 12(S)-HETE is a potent stimulator of smooth muscle cell and leukocyte migration. In addition, this metabolite can induce reversible endothelial cell retraction allowing tumor cell access to the subendothelial matrix, which is not activated by 12(R)-HETE . Furthermore, studies show that a potential use of this molecule could be in preferentially attracting eosinophils to tissue reactions associated with platelet activation.