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STE:Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
15-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one , CAS No.I609011, Inhibitor of mitogen-activated protein kinase kinase kinase 5

15-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one , CAS No.I609011, Inhibitor of mitogen-activated protein kinase kinase kinase 5

Item Number

I609011

Grouped product items
SKU	Size	Availability	Price	Qty
I609011-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I609011-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 26
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase kinase kinase 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C25H28N8O2/c1-31(2)11-12-33-16-19(15-27-33)18-8-9-22-20(14-18)25(34)29-23-7-5-6-21(28-23)24-30-26-17-32(24)10-3-4-13-35-22/h5-9,14-17H,3-4,10-13H2,1-2H3,(H,28,29,34)
InChi Key	JGKCBXMHIQSQHJ-UHFFFAOYSA-N
Canonical SMILES	CN(CCn1ncc(c1)c1ccc2c(c1)C(=O)Nc1cccc(n1)c1n(CCCCO2)cnn1)C
Isomeric SMILES	CN(C)CCN1C=C(C=N1)C2=CC3=C(C=C2)OCCCCN4C=NN=C4C5=NC(=CC=C5)NC3=O
PubChem CID	142411827

PubChem CID	142411827

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1. Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H. (2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.. Genes Dev, 22 (11): (1451-64). [PMID:18519638]
2. Himmelbauer MK, Xin Z, Jones JH, Enyedy I, King K, Marcotte DJ, Murugan P, Santoro JC, Hesson T, Spilker K et al.. (2019) Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.. J Med Chem, 62 (23): (10740-10756). [PMID:31710475]

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