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G protein-coupled receptors (GPCRs)
Prostanoid receptors
15(R)-15-methyl Prostaglandin D2 - A solution in methyl acetate, high purity , CAS No.210978-26-0, Agonist of DP 2 receptor

15(R)-15-methyl Prostaglandin D2 - A solution in methyl acetate, high purity , CAS No.210978-26-0, Agonist of DP 2 receptor

Item Number

R348792

Grouped product items
SKU	Size	Availability	Price	Qty
R348792-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$114.90
R348792-500μg	500μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90

a potent CRTH2/DP2 receptor agonist

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Basic Description

Synonyms	15(R)-15-methyl Prostaglandin D2\|210978-26-0\|15-methyl-15R-PGD2\|15(R)-15-methyl-PGD2\|(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3R)-3-hydroxy-3-methyloct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid\|15R-methyl-prostaglandin D2\|15-methyl-15R-Prostaglandin D2\|Prosta-5
Specifications & Purity	A solution in methyl acetate
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	AGONIST
Mechanism of action	Agonist of DP 2 receptor
Product Description	15(R)-15-methyl PGD2 is a selective, potent agonist for the CRTH2/DP2 receptor. The EC\|50\|values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast, the EC\|50\|for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3R)-3-hydroxy-3-methyloct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
INCHI	InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-18,22,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,21-/m1/s1
InChi Key	CTXLUMAOXBULOZ-BKVRKCTKSA-N
Canonical SMILES	CCCCCC(C)(C=CC1C(C(CC1=O)O)CC=CCCCC(=O)O)O
Isomeric SMILES	CCCCC[C@](C)(/C=C/[C@@H]1[C@H]([C@H](CC1=O)O)C/C=C\CCCC(=O)O)O
PubChem CID	5283097
Molecular Weight	366.5

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Boil Point(°C)	57-58° C
Melt Point(°C)	-98° C

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