17-DMAG (Alvespimycin) HCl - ≥98%, high purity , CAS No.467214-21-7

Item Number

D129714

Grouped product items
SKU	Size	Availability	Price	Qty
D129714-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$129.90
D129714-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$325.90

Potent Hsp90\xa0inhibitor

Basic Description

Synonyms	NSC 707545 \| Amrubicin hydrochloride (JAN/USAN) \| 17-DMAG, Hydrochloride Salt \| ALVESPIMYCIN HYDROCHLORIDE [WHO-DD] \| TRISTEARYLORTHOFORMATE \| AKOS024457196 \| Alvespimycin hydrochloride \| Hydrochloride of (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-((2- (dimethy
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	17-DMAG, Hydrochloride Salt is a water-soluble analog of 17-AAG and geldanamycin . 17-DMAG, Hydrochloride Salt binds the ATP binding site of Hsp90 and inhibits its chaperone activity. It displays more potent antitumor activity than 17-AAG (mean GI50 value
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	17-DMAG (Alvespimycin) HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. An Hsp90 inhibitor

Names and Identifiers

IUPAC Name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride
INCHI	InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
InChi Key	DFSYBWLNYPEFJK-IHLRWNDRSA-N
Canonical SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC.Cl
PubChem CID	9852573
Molecular Weight	653.21

Lot Number

Certificate Type

Date

Item

Certificate of Analysis

Apr 13, 2023

D129714

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Basic Description