17-phenyl trinor PGF2α isopropyl ester - A solution in ethanol, high purity , CAS No.130209-76-6

Item Number

P355686

Grouped product items
SKU	Size	Availability	Price	Qty
P355686-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$274.90
P355686-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,196.90

a F-series prostaglandin analog and potent FP receptor agonist

Basic Description

Synonyms	130209-76-6\|17-phenyl-trinor-PGF2alpha isopropyl ester\|dehydrolatanoprost\|Bimatoprost isopropyl ester\|1IFH52MD8T\|propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate\|17-Phenyl trinor Pgf2alpha-Ip
Specifications & Purity	A solution in ethanol
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	17-phenyl trinor PGF2α isopropyl ester is the isopropyl ester of the free acid prostaglandin which corresponds to bimatoprost. This free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The bimatoprost isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.5 At the dose of 3 mg/eye in the monkey, bimatoprost isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.

Names and Identifiers

IUPAC Name	propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate
INCHI	InChI=1S/C26H38O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,16-17,19,21-25,27-29H,4,9,12-15,18H2,1-2H3/b8-3-,17-16+/t21-,22+,23+,24-,25+/m0/s1
InChi Key	JGZRPRSJSQLFBO-FWPUOYPASA-N
Canonical SMILES	CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Isomeric SMILES	CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O
PubChem CID	5283107
Molecular Weight	430.6

Solubility

Soluble in DMSO (~30 mg/ml), DMF (~30 mg/ml), and 1:1 solution of ethanol: PBS (pH 7.2) (~1 mg/ml).

Refractive Index

n20D1.58 (Predicted)

Boil Point(°C)

78° C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help.

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Basic Description