Grouped product items

SKU

Size

Availability

Price

Qty

P336631-500μg

500μg

Available within 8-12 weeks(?)

$44.90

P336631-1mg

1mg

Available within 8-12 weeks(?)

$169.90

Basic Description

Synonyms	17-PHENYL TRINOR PROSTAGLANDIN E2\|17-phenyl-omega-trinor-PGE2\|17-phenyl-trinor-PGE2\|17-phenyl-trinor-prostaglandin E2\|38315-43-4\|17-phenyl-omega-trinor-prostaglandin E2\|17-phenyltrinor-PGE2\|(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-en
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor
Product Description	17-phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.1,2 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM. It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.With an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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GPR35 Tchem G-protein coupled receptor 35 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FFAR4 Tchem Free fatty acid receptor 4 0 Activities

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FPR2 Tchem N-formyl peptide receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype 1 Activities

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PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 0 Activities

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PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype 3 Activities

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PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype 2 Activities

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RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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APLNR Tchem Apelin receptor 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

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AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
INCHI	InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
InChi Key	FOBVMYJQWZOGGJ-XYRJXBATSA-N
Canonical SMILES	C1C(C(C(C1=O)CC=CCCCC(=O)O)C=CC(CCC2=CC=CC=C2)O)O
Isomeric SMILES	C1[C@H]([C@@H]([C@H](C1=O)C/C=C\CCCC(=O)O)/C=C/[C@H](CCC2=CC=CC=C2)O)O
Alternate CAS	38315-43-4
PubChem CID	5283068
MeSH Entry Terms	17-Ph-trinor-PGE2;17-phenyl-omega-trinor PGE2;17-phenyltrinorprostaglandin E2
Molecular Weight	386.48

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
B2423528	Certificate of Analysis	Jan 13, 2024	P336631
L2320171	Certificate of Analysis	Dec 06, 2023	P336631

Chemical and Physical Properties

Solubility	Soluble in ethanol (~100 mg/ml), PBS (pH 7.2) (~0.8 mg/ml), DMF, DMSO, acetone, and ethyl acetate.

References

1. Theiler A, Konya V, Pasterk L, Maric J, Bärnthaler T, Lanz I, Platzer W, Schuligoi R, Heinemann A. (2016) The EP1/EP3 receptor agonist 17-pt-PGE₂ acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation.. Vascul Pharmacol, 87 (3): (180-189). [PMID:27664754]

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SKU	Size	Availability	Price	Qty
P336631-500μg	500μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$44.90
P336631-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90

17-phenyl trinor Prostaglandin E₂ - 98%, high purity , CAS No.38315-43-4, Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor