1α,25-Dihydroxyvitamin D₃ (6,19,19-d₃) solution - 100μg/mL in ethanol, 97 atom% D, 96% (CP), high purity , CAS No.128723-16-0

Item Number

D466245

Grouped product items
SKU	Size	Availability	Price	Qty
D466245-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,151.90

Basic Description

Synonyms	Calcitriol-d3 \| 128723-16-0 \| (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]-1-deuterioethylidene]-4-(dideuteriomethylidene)cyclohexane-1,3-diol \| 1,25-Dihydroxyvitamin-D3-[2H3] \| AKO
Specifications & Purity	100μg/mL in ethanol, 97 atom% D, 96% (CP)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	1α,25-Dihydroxyvitamin D3[1,25(OH)2D3], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.1α,25-Dihydroxyvitamin D3(6,19,19-d3) is a deuterated vitamin D3wherein C-6 and C-19 protons are replaced by deuterium.1α,25-Dihydroxyvitamin D3(6,19,19-d3) can be used as a stable isotope internal standard for accurate data interpretation in specific biological samples by mass spectrometry.

Names and Identifiers

IUPAC Name	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]-1-deuterioethylidene]-4-(dideuteriomethylidene)cyclohexane-1,3-diol
INCHI	InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1/i2D2,11D
InChi Key	GMRQFYUYWCNGIN-POLIPXRRSA-N
Canonical SMILES	CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES	[2H]C(=C\1[C@H](C[C@@H](C/C1=C(\[2H])/C=C/2\CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C)O)O)[2H]
PubChem CID	91820610
UN Number	1170
Molecular Weight	419.65

Flash Point(°F)

57.2 °F - closed cup

Flash Point(°C)

14.0 °C - closed cup

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H330:Fatal if inhaled H372:Causes damage to organs through prolonged or repeated exposure H301+H311:Toxic if swallowed or in contact with skin
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
RIDADR	UN1170 - class 3 - PG 2 - Ethanol, solution

References

1. Wai W Cheung, Sheng Hao, Zhen Wang, Wei Ding, Ronghao Zheng, Alex Gonzalez, Jian-Ying Zhan, Ping Zhou, Shiping Li, Mary C Esparza, Hal M Hoffman, Richard L Lieber, Robert H Mak,. (2019-11-14) Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.. Journal of cachexia, sarcopenia and muscle, 11 ((1)): ( 120-134 ). [PMID:31721480]

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Basic Description