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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H587593-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
H587593-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $52.90 | |
H587593-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $114.90 |
Synonyms | 1H-Indole-5-carboxamide|1670-87-7|Indole-5-carboxamide|SD-169|SD169|SD 169|5-Carboxamidoindole|1~{H}-indole-5-carboxamide|MLS006010711|SCHEMBL170646|CHEMBL1435541|BDBM93020|CHEBI:93599|1H-Indole-5-carboxamide, 97%|DTXSID50566323|GQMYQEAXTITUAE-UHFFFAOYSA- |
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Specifications & Purity | ≥97% |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Product Description |
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation.
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IUPAC Name | 1H-indole-5-carboxamide |
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INCHI | InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12) |
InChi Key | GQMYQEAXTITUAE-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C=CN2)C=C1C(=O)N |
Isomeric SMILES | C1=CC2=C(C=CN2)C=C1C(=O)N |
WGK Germany | 3 |
PubChem CID | 14973220 |
Molecular Weight | 160.17 |
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Solubility | DMSO: 10 mg/mL (62.43 mM) |
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Sensitivity | light sensitive |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |