2-(14,15-Epoxyeicosatrienoyl) Glycerol - A solution in acetonitrile,≥95%, high purity , CAS No.848667-56-1

Item Number

E341170

Grouped product items
SKU	Size	Availability	Price	Qty
E341170-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$366.90
E341170-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$691.90

a TACE activator which increases DNA synthesis

Basic Description

Synonyms	2-14,15-EG \| 2-glyceryl 14,15-epoxy-(5Z,8Z,11Z)-icosatrienoate \| 2-Hydroxy-1-(hydroxymethyl)ethyl (5Z,8Z,11Z)-13-(3-pentyl-2-oxiranyl)-5,8,11-tridecatrienoate \| 2-glyceryl-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate \| DTXSID901118996 \| PD019627 \| Q27225428 \|
Specifications & Purity	A solution in acetonitrile,≥95%
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	2-(14,15-Epoxyeicosatrienoyl) Glycerol (2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. 2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 μM. In these cells, 2-14,15-EG activates the metalloprotease ADAM17 (TACE), which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway.

Names and Identifiers

IUPAC Name	1,3-dihydroxypropan-2-yl (5Z,8Z,11Z)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoate
INCHI	InChI=1S/C23H38O5/c1-2-3-12-15-21-22(28-21)16-13-10-8-6-4-5-7-9-11-14-17-23(26)27-20(18-24)19-25/h4,6-7,9-10,13,20-22,24-25H,2-3,5,8,11-12,14-19H2,1H3/b6-4-,9-7-,13-10-
InChi Key	LPMVKZXODWQHGJ-ILYOTBPNSA-N
Canonical SMILES	CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)OC(CO)CO
Isomeric SMILES	CCCCCC1C(O1)C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO
PubChem CID	53481916
Molecular Weight	394.54

Solubility

Soluble in DMSO (~10 mg/ml), DMF (~10 mg/ml), aqueous solutions, and ethanol (~50 mg/ml).

Refractive Index

n20D1.51 (Predicted)

Boil Point(°C)

84° C

Solution Calculators

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Basic Description