2-(14,15-Epoxyeicosatrienoyl) Glycerol - A solution in acetonitrile,≥95%, high purity , CAS No.848667-56-1

  • ≥95%
  • A solution in acetonitrile
Item Number
E341170
Grouped product items
SKUSizeAvailabilityPrice Qty
E341170-25μg
25μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$366.90
E341170-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$691.90

a TACE activator which increases DNA synthesis

Basic Description

Synonyms2-(14,15-Epoxyeicosatrienoyl) Glycerol | 848667-56-1 | 2-14,15-EG | 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoate | 2-glyceryl 14,15-epoxy-(5Z,8Z,11Z)-icosatrienoate | 2-glyceryl 14,15-EET | 14,15-EET 2-glyceryl ester | CHEBI:132
Specifications & PurityA solution in acetonitrile,≥95%
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

2-(14,15-Epoxyeicosatrienoyl) Glycerol (2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. 2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 μM. In these cells, 2-14,15-EG activates the metalloprotease ADAM17 (TACE), which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway.

Names and Identifiers

IUPAC Name 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoate
INCHI InChI=1S/C23H38O5/c1-2-3-12-15-21-22(28-21)16-13-10-8-6-4-5-7-9-11-14-17-23(26)27-20(18-24)19-25/h4,6-7,9-10,13,20-22,24-25H,2-3,5,8,11-12,14-19H2,1H3/b6-4-,9-7-,13-10-
InChi Key LPMVKZXODWQHGJ-ILYOTBPNSA-N
Canonical SMILES CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)OC(CO)CO
Isomeric SMILES CCCCCC1C(O1)C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO
PubChem CID 53481916
Molecular Weight 394.54

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (~10 mg/ml), DMF (~10 mg/ml), aqueous solutions, and ethanol (~50 mg/ml).
Refractive Indexn20D1.51 (Predicted)
Boil Point(°C)84° C

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