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Basic Description
| Specifications & Purity | ≥95% |
|---|---|
| Legal Information | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Description This heterobifunctional, PEGylated crosslinker 2-(2-((7-(tert-butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC®molecules) fortargeted protein degradationwhere the linker region is referred to as 2-2-6. |
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Related Documents
References
| 1. Ashton C Lai, Momar Toure, Doris Hellerschmied, Jemilat Salami, Saul Jaime-Figueroa, Eunhwa Ko, John Hines, Craig M Crews,. (2015-11-26) Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.. Angewandte Chemie (International ed. in English), 55 ((2)): ( 807-810 ). [PMID:26593377] |