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Nuclear Receptors
Liver X receptor-like receptors
2-[2-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]isoindole-1,3-dione , CAS No.E608787, Antagonist of Liver X receptor-β

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2-[2-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]isoindole-1,3-dione , CAS No.E608787, Antagonist of Liver X receptor-β

Moligand™

PubChem CID: 122192273

Item Number

E608787

Grouped product items
SKU	Size	Availability	Price	Qty
E608787-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
E608787-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

Liver X receptor-β Antagonist

Basic Description

Synonyms	compound 17l
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of Liver X receptor-β

Associated Targets

NR1H2 Tchem Oxysterols receptor LXR-beta 1 Activities

Discover Target: NR1H2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H3 Tchem Oxysterols receptor LXR-alpha 0 Activities

Discover Target: NR1H3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARA Tclin Peroxisome proliferator-activated receptor alpha 0 Activities

Discover Target: PPARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Discover Target: PPARD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[2-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]isoindole-1,3-dione
INCHI	InChI=1S/C24H19NO4/c1-28-21-14-12-16(15-22(21)29-2)11-13-17-7-3-6-10-20(17)25-23(26)18-8-4-5-9-19(18)24(25)27/h3-15H,1-2H3/b13-11+
InChi Key	MKFOSSOUEAENMG-ACCUITESSA-N
Canonical SMILES	COc1ccc(cc1OC)/C=C/c1ccccc1N1C(=O)c2c(C1=O)cccc2
Isomeric SMILES	COC1=C(C=C(C=C1)/C=C/C2=CC=CC=C2N3C(=O)C4=CC=CC=C4C3=O)OC
PubChem CID	122192273

Database links

PubChem CID	122192273
ChEMBL Ligand	CHEMBL3623107

Certificates

Certificate of Analysis(COA)

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References

1. Nomura S, Endo-Umeda K, Aoyama A, Makishima M, Hashimoto Y, Ishikawa M. (2015) Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.. ACS Med Chem Lett, 6 (8): (902-7). [PMID:26288691]

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