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2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid - A solution in ethanol,≥96%, high purity , CAS No.64054-40-6
Basic Description Synonyms CAY10580|64054-40-6|7-[2-(3-HYDROXYOCTYL)-5-OXOPYRROLIDIN-1-YL]HEPTANOIC ACID|2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid|CHEMBL15096|7-(2-(3-Hydroxyoctyl)-5-oxopyrrolidin-1-yl)heptanoic acid|CAY 10580|CAY-10580|DTXSID10658096|CHEBI:194210|BDBM50 Specifications & Purity ≥96%, A solution in ethanol Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Kι = 35 nM) relative to the EP1, EP2, and EP3 receptors (Kι = 3,000, 2,000, and >3,000 nM, respectively). This chemical stimulates cAMP formation in excised murine ovaries. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that plays important roles in bone formation and resorption, cancer and atherosclerosis by elevating the second messenger cAMP.
Product Properties pKa pKa: 4.77 (Predicted) Ki Data EP4: Ki= 35 nM; EP2: Ki= 2000 nM; EP1: Ki= 3000 nM; EP3: Ki= >3000 nM; TXA2R: Ki= >13 μM (HEK293 ebna cells )
Names and Identifiers IUPAC Name 7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid INCHI InChI=1S/C19H35NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h16-17,21H,2-15H2,1H3,(H,23,24) InChi Key CBWGHEDGUILASE-UHFFFAOYSA-N Canonical SMILES CCCCCC(CCC1CCC(=O)N1CCCCCCC(=O)O)O Isomeric SMILES CCCCCC(CCC1CCC(=O)N1CCCCCCC(=O)O)O PubChem CID 44269516 UN Number 1170 Packing Group II Molecular Weight 341.49
Chemical and Physical Properties Solubility Soluble in water (2.5 mg/ml at 25° C), PBS (pH 7.2) (~2.5 mg/ml), DMF (~10 mg/ml), DMSO (~10 mg/ml), and ethanol. Refractive Index n20D1.49 (Predicted) Boil Point(°C) 78° C
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