2-Amino-4-(4-hydroxymethyl)phenyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile , CAS No.A609238, Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of inhibitor of nuclear factor kappa B kinase subunit beta

Item Number

A609238

Grouped product items
SKU	Size	Availability	Price	Qty
A609238-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A609238-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Synonyms

compound 47

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of inhibitor of nuclear factor kappa B kinase subunit beta

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-Amino-4-(4-hydroxymethyl)phenyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
INCHI	InChI=1S/C14H11N5O/c15-5-10-6-17-13-11(10)12(18-14(16)19-13)9-3-1-8(7-20)2-4-9/h1-4,6,20H,7H2,(H3,16,17,18,19)
InChi Key	BJQSJIPGTMBHKF-UHFFFAOYSA-N
Canonical SMILES	OCc1ccc(cc1)c1nc(N)nc2c1c(C#N)c[nH]2
Isomeric SMILES	C1=CC(=CC=C1CO)C2=C3C(=CNC3=NC(=N2)N)C#N
PubChem CID	129320519

References

1. Anthony NG, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, Gamble C, Gray AI, Harvey AL, Hatziieremia S et al.. (2017) Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.. J Med Chem, 60 (16): (7043-7066). [PMID:28737909]

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Basic Description