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2-Amino-6-(2,3-dichlorobenzyl)-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one , CAS No.A609154, Allosteric modulator of CCR2;Allosteric modulator of CCR5

  • Moligand™
Item Number
A609154
Grouped product items
SKUSizeAvailabilityPrice Qty
A609154-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,000.90
A609154-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonymscompound 39
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of CCR2;Allosteric modulator of CCR5

Associated Targets

CCR2 Tchem C-C chemokine receptor type 2 9 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CCR5 Tclin C-C chemokine receptor type 5 7 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-Amino-6-(2,3-dichlorobenzyl)-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
INCHI InChI=1S/C15H15Cl2N5O/c1-7(2)12-9(6-8-4-3-5-10(16)11(8)17)13(23)22-15(19-12)20-14(18)21-22/h3-5,7H,6H2,1-2H3,(H3,18,19,20,21)
InChi Key KLBHHUODQVCBKX-UHFFFAOYSA-N
Canonical SMILES Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
Isomeric SMILES CC(C)C1=C(C(=O)N2C(=N1)N=C(N2)N)CC3=C(C(=CC=C3)Cl)Cl
PubChem CID 145996522

Certificates

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Related Documents

References

1. Zhao Q.  (2010)  Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases..  J Leukoc Biol,  88  (1): (41-55).  [PMID:20360402]
2. Friedman SL, Ratziu V, Harrison SA, Abdelmalek MF, Aithal GP, Caballeria J, Francque S, Farrell G, Kowdley KV, Craxi A et al..  (2018)  A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis..  Hepatology,  67  (5): (1754-1767).  [PMID:28833331]
3. Fantuzzi L, Tagliamonte M, Gauzzi MC, Lopalco L.  (2019)  Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders..  Cell Mol Life Sci,  76  (24): (4869-4886).  [PMID:31377844]
4. Ortiz Zacarías NV, van Veldhoven JPD, den Hollander LS, Dogan B, Openy J, Hsiao YY, Lenselink EB, Heitman LH, IJzerman AP.  (2019)  Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5..  J Med Chem,  62  (24): (11035-11053).  [PMID:31742400]

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