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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A609154-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,000.90 | |
A609154-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Synonyms | compound 39 |
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Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of CCR2;Allosteric modulator of CCR5 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 2-Amino-6-(2,3-dichlorobenzyl)-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one |
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INCHI | InChI=1S/C15H15Cl2N5O/c1-7(2)12-9(6-8-4-3-5-10(16)11(8)17)13(23)22-15(19-12)20-14(18)21-22/h3-5,7H,6H2,1-2H3,(H3,18,19,20,21) |
InChi Key | KLBHHUODQVCBKX-UHFFFAOYSA-N |
Canonical SMILES | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C |
Isomeric SMILES | CC(C)C1=C(C(=O)N2C(=N1)N=C(N2)N)CC3=C(C(=CC=C3)Cl)Cl |
PubChem CID | 145996522 |
GPCRdb Ligand | compound 39 [PMID: 31742400] |
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PubChem CID | 145996522 |
Enter Lot Number to search for COA:
1. Zhao Q. (2010) Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases.. J Leukoc Biol, 88 (1): (41-55). [PMID:20360402] |
2. Friedman SL, Ratziu V, Harrison SA, Abdelmalek MF, Aithal GP, Caballeria J, Francque S, Farrell G, Kowdley KV, Craxi A et al.. (2018) A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.. Hepatology, 67 (5): (1754-1767). [PMID:28833331] |
3. Fantuzzi L, Tagliamonte M, Gauzzi MC, Lopalco L. (2019) Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders.. Cell Mol Life Sci, 76 (24): (4869-4886). [PMID:31377844] |
4. Ortiz Zacarías NV, van Veldhoven JPD, den Hollander LS, Dogan B, Openy J, Hsiao YY, Lenselink EB, Heitman LH, IJzerman AP. (2019) Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5.. J Med Chem, 62 (24): (11035-11053). [PMID:31742400] |