a protein kinase inhibitor that can alter cell cycle checkpoints
Basic Description
Synonyms
2-AMINOPURINE DIHYDROCHLORIDE|76124-64-6|2-Aminopurine (hydrochloride)|1428126-74-2|7H-Purin-2-amine;dihydrochloride|2-Aminopurine (dihydrochloride)|Isoadenine Dihydrochloride|DTXSID90696517|9H-Purin-2-amine Dihydrochloride|HY-W012642A|1H-PURIN-2-AMINE DI
Specifications & Purity
98%
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Product Description
2-Aminopurine Dihydrochloride is a purine analog that acts as a protein kinase inhibitor. The compound is a mutagen that can incorporate into DNA and has been used as a fluorescent probe. Studies indicate that it can alter checkpoints in the phases of the cell cycle, in particular alter cells to enter mitosis in S-phase arrested cells incorrectly and override a γ radiation induced G|2|block. Additionally, it has been demonstrated that 2-Aminopurine Dihydrochloride inhibits PITSLREβ1 protein kinase activity, and that it can alter the structure and dynamics of DNA. 2-Aminopurine Dihydrochloride does not effect the protein kinase activity of p34cdc2. 2-Aminopurine Dihydrochloride is an inhibitor of PKR.
