Grouped product items

SKU

Size

Availability

Price

Qty

E102208-25ml

25ml

In stock

$36.90

E102208-100ml

100ml

In stock

$129.90

E102208-500ml

500ml

Available within 4-8 weeks(?)

$584.90

Basic Description

Synonyms	2-Ethylhexyl 4-(dimethylamino)benzoate\|21245-02-3\|Padimate O\|2-ETHYLHEXYL 4-DIMETHYLAMINOBENZOATE\|Escalol 507\|Padimate-O\|Octyl dimethyl PABA\|Arlatone UVB\|Eusolex 6007\|2-Ethylhexyl p-dimethylaminobenzoate\|Benzoic acid, 4-(dimethylamino)-, 2-ethylhexyl este
Specifications & Purity	≥98%
Shipped In	Normal

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

Discover Target: PIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

Discover Target: PLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Discover Target: LMNA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Discover Target: BAZ2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLPP Tchem ATP-dependent Clp protease proteolytic subunit, mitochondrial 0 Activities

Discover Target: CLPP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCL8 Tchem Interleukin-8 0 Activities

Discover Target: CXCL8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488183116
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183116
IUPAC Name	2-ethylhexyl 4-(dimethylamino)benzoate
INCHI	InChI=1S/C17H27NO2/c1-5-7-8-14(6-2)13-20-17(19)15-9-11-16(12-10-15)18(3)4/h9-12,14H,5-8,13H2,1-4H3
InChi Key	WYWZRNAHINYAEF-UHFFFAOYSA-N
Canonical SMILES	CCCCC(CC)COC(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES	CCCCC(CC)COC(=O)C1=CC=C(C=C1)N(C)C
WGK Germany	2
PubChem CID	30541
Molecular Weight	277.4
Reaxy-Rn	5946517

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
J1211051	Certificate of Analysis	Jul 16, 2024	E102208
G2307600	Certificate of Analysis	Jul 15, 2023	E102208
C1911198	Certificate of Analysis	Jan 11, 2023	E102208
F2221216	Certificate of Analysis	Jun 07, 2022	E102208
F2221512	Certificate of Analysis	Jun 07, 2022	E102208
D2310285	Certificate of Analysis	Dec 15, 2021	E102208

Chemical and Physical Properties

Solubility	Insoluble in water; Soluble in Alcohol; Slightly soluble in Ether
Sensitivity	Air Sensitive
Refractive Index	1.542
Flash Point(°F)	113 °C
Flash Point(°C)	113°C
Boil Point(°C)	325°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany	2
Reaxy-Rn	5946517
Merck Index	3232

References

1. S H Dromgoole,H I Maibach. (1990-06-01) Sunscreening agent intolerance: contact and photocontact sensitization and contact urticaria.. Journal of the American Academy of Dermatology, 22 ((6 Pt 1)): (1068-1078). [PMID:2196288]
2. R Bestak,R S Barnetson,M R Nearn,G M Halliday. (1995-09-01) Sunscreen protection of contact hypersensitivity responses from chronic solar-simulated ultraviolet irradiation correlates with the absorption spectrum of the sunscreen.. The Journal of investigative dermatology, 105 ((3)): (345-351). [PMID:7665910]
3. R Jiang,C G Hayden,R J Prankerd,M S Roberts,H A Benson. (1996-06-28) High-performance liquid chromatographic assay for common sunscreening agents in cosmetic products, bovine serum albumin solution and human plasma.. Journal of chromatography. B, Biomedical applications, 682 ((1)): (137-145). [PMID:8832434]
4. C Ricci,S Vaccari,M Cavalli,C Vincenzi. (1997-09-01) Contact sensitization to sunscreens.. American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 8 ((3)): (165-166). [PMID:9249286]
5. T M Morgan,B L Reed,B C Finnin. (1998-10-06) Enhanced skin permeation of sex hormones with novel topical spray vehicles.. Journal of pharmaceutical sciences, 87 ((10)): (1213-1218). [PMID:9758679]
6. M Gulston,J Knowland. (1999-09-08) Illumination of human keratinocytes in the presence of the sunscreen ingredient Padimate-O and through an SPF-15 sunscreen reduces direct photodamage to DNA but increases strand breaks.. Mutation research, 444 ((1)): (49-60). [PMID:10477339]
7. S Scalia,S Villani,A Casolari. (2000-03-04) Inclusion complexation of the sunscreen agent 2-ethylhexyl-p-dimethylaminobenzoate with hydroxypropyl-beta-cyclodextrin: effect on photostability.. The Journal of pharmacy and pharmacology, 51 ((12)): (1367-1374). [PMID:10678490]
8. Rajagopal Krishnan,Aaron Carr,Elizabeth Blair,Thomas M Nordlund. (2004-08-05) Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres.. Photochemistry and photobiology, 79 ((6)): (531-539). [PMID:15291305]
9. Joseph A Nicolazzo,Barry L Reed,Barrie C Finnin. (2005-03-01) Enhanced buccal mucosal retention and reduced buccal permeability of estradiol in the presence of padimate O and Azone: a mechanistic study.. Journal of pharmaceutical sciences, 94 ((4)): (873-882). [PMID:15736191]
10. Ana Gil-Vergara,Cristina Blasco,Yolanda Picó. (2007-07-25) Determination of 2-isopropyl thioxanthone and 2-ethylhexyl-4-dimethylaminobenzoate in milk: comparison of gas and liquid chromatography with mass spectrometry.. Analytical and bioanalytical chemistry, 389 ((2)): (605-617). [PMID:17646969]
11. Rajagopal Krishnan,Thomas M Nordlund. (2007-10-27) Fluorescence dynamics of three UV-B sunscreens.. Journal of fluorescence, 18 ((1)): (203-217). [PMID:17963026]
12. Gianni Sagratini,Giovanni Caprioli,Gloria Cristalli,Dario Giardiná,Massimo Ricciutelli,Rosaria Volpini,Yanting Zuo,Sauro Vittori. (2008-05-20) Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.. Journal of chromatography. A, 1194 ((2)): (213-220). [PMID:18486139]
13. J G March,C Genestar,B M Simonet. (2009-04-07) Determination of 2-ethylhexyl 4-(dimethylamino) benzoate using membrane-assisted liquid-liquid extraction and gas chromatography-mass spectrometric detection.. Analytical and bioanalytical chemistry, 394 ((3)): (883-891). [PMID:19347661]
14. Yi-Hung Tsai,Ko-Feng Lee,Yaw-Bin Huang,Chi-Te Huang,Pao-Chu Wu. (2010-01-12) In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.. International journal of pharmaceutics, 388 ((1-2)): (257-262). [PMID:20060453]
15. M Krause,A Klit,M Blomberg Jensen,T Søeborg,H Frederiksen,M Schlumpf,W Lichtensteiger,N E Skakkebaek,K T Drzewiecki. (2012-05-23) Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.. International journal of andrology, 35 ((3)): (424-436). [PMID:22612478]
16. Marina G Pintado-Herrera,Eduardo González-Mazo,Pablo A Lara-Martín. (2014-12-03) Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).. Analytica chimica acta, 851 (1-13). [PMID:25440658]
17. S C Cunha,J O Fernandes,L Vallecillos,G Cano-Sancho,J L Domingo,E Pocurull,F Borrull,A L Maulvault,F Ferrari,M Fernandez-Tejedor,F Van den Heuvel,M Kotterman. (2015-05-20) Co-occurrence of musk fragrances and UV-filters in seafood and macroalgae collected in European hotspots.. Environmental research, 143 ((Pt B)): (65-71). [PMID:25985745]
18. Yida Zhang,Yaoxia Yang,Yi Li,Min Zhang,Xuemei Wang,Xinzhen Du. (2015-05-23) Growth of cedar-like Au nanoparticles coating on an etched stainless steel wire and its application for selective solid-phase microextraction.. Analytica chimica acta, 876 (55-62). [PMID:25998458]
19. Juan L Benedé,Alberto Chisvert,Dimosthenis L Giokas,Amparo Salvador. (2015-11-26) Determination of ultraviolet filters in bathing waters by stir bar sorptive-dispersive microextraction coupled to thermal desorption-gas chromatography-mass spectrometry.. Talanta, 147 (246-252). [PMID:26592603]
20. Daniel Molins-Delgado,Manuel Máñez,Ana Andreu,Fernando Hiraldo,Ethel Eljarrat,Damià Barceló,M Silvia Díaz-Cruz. (2017-09-06) A Potential New Threat to Wild Life: Presence of UV Filters in Bird Eggs from a Preserved Area.. Environmental science & technology, 51 ((19)): (10983-10990). [PMID:28870065]
21. V C Dunkel,R H San,J W Harbell,H E Seifried,T P Cameron. (1992-01-01) Evaluation of the mutagenicity of an N-nitroso contaminant of the sunscreen Padimate O: N-nitroso-N-methyl-p-aminobenzoic acid, 2-ethylhexyl ester (NPABAO).. Environmental and molecular mutagenesis, 20 ((3)): (188-198). [PMID:1396609]
22. J A Johnson,R M Fusaro. (1992-01-01) Broad-spectrum photoprotection: the roles of tinted auto windows, sunscreens and browning agents in the diagnosis and treatment of photosensitivity.. Dermatology (Basel, Switzerland), 185 ((4)): (237-241). [PMID:1477415]
23. R N Loeppky,R Hastings,J Sandbothe,D Heller,Y Bao,D Nagel. (1991-01-01) Nitrosation of tertiary aromatic amines related to sunscreen ingredients.. IARC scientific publications, (105) ((105)): (244-252). [PMID:1855862]
24. J Knowland,E A McKenzie,P J McHugh,N A Cridland. (1993-06-21) Sunlight-induced mutagenicity of a common sunscreen ingredient.. FEBS letters, 324 ((3)): (309-313). [PMID:8405372]
25. D A Volmer,J O Lay,M Billedeau,D L Vollmer. (1996-01-01) Characterization of nitrosation products in cosmetics raw materials by liquid chromatography/mass spectrometry techniques.. Rapid communications in mass spectrometry : RCM, 10 ((6)): (715-720). [PMID:8624419]
26. P J McHugh,J Knowland. (1997-08-01) Characterization of DNA damage inflicted by free radicals from a mutagenic sunscreen ingredient and its location using an in vitro genetic reversion assay.. Photochemistry and photobiology, 66 ((2)): (276-281). [PMID:9277149]
27. T M Morgan,R A Parr,B L Reed,B C Finnin. (1998-10-06) Enhanced transdermal delivery of sex hormones in swine with a novel topical aerosol.. Journal of pharmaceutical sciences, 87 ((10)): (1219-1225). [PMID:9758680]
28. Gamal M M El Maghraby,Michael Campbell,Barrie C Finnin. (2005-10-04) Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes.. International journal of pharmaceutics, 305 ((1-2)): (90-104). [PMID:16199131]
29. Zacarías León-González,Carlos Ferreiro-Vera,Feliciano Priego-Capote,María Dolores Luque de Castro. (2011-04-13) Targeting metabolomics analysis of the sunscreen agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate in human urine by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry with liquid chromatography-time-of-flight/mass spectrometry confirmation.. Journal of chromatography. A, 1218 ((20)): (3013-3021). [PMID:21481400]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

2-Ethylhexyl 4-(dimethylamino)benzoate - 98%, high purity , CAS No.21245-02-3