2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one - >98.0%(HPLC), high purity , CAS No.168425-64-7

Item Number

M157859

• Synonyms: Compound 401|168425-64-7|2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one|2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one|TN9PWB4UM5|CHEMBL179242|2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE|2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one|2-M
• Specifications & Purity: >98.0%(HPLC)
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Dry ice

Product Description

Product Introduction

A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.