Skip to the beginning of the images gallery

(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide , CAS No.R608974, Inhibitor of protein kinase C delta;Inhibitor of Rho associated coiled-coil containing protein kinase 2;Inhibitor of ribosomal protein S6 kinase A4;Inhibitor of ribosomal protein S6 kinase A5

Moligand™

PubChem CID: 155749520

Item Number

R608974

Grouped product items
SKU	Size	Availability	Price	Qty
R608974-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$237.90
R608974-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$828.90

View related series

protein kinase C delta Inhibitor Rho associated coiled-coil containing protein kinase 2 Inhibitor ribosomal protein S6 kinase A4 Inhibitor ribosomal protein S6 kinase A5 Inhibitor

Basic Description

Synonyms	compound 23
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein kinase C delta;Inhibitor of Rho associated coiled-coil containing protein kinase 2;Inhibitor of ribosomal protein S6 kinase A4;Inhibitor of ribosomal protein S6 kinase A5

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK2 Tclin Rho-associated protein kinase 2 0 Activities

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG1 Tchem cGMP-dependent protein kinase 1 0 Activities

Discover Target: PRKG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCD Tclin Protein kinase C delta type 0 Activities

Discover Target: PRKCD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA5 Tchem Ribosomal protein S6 kinase alpha-5 0 Activities

Discover Target: RPS6KA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIMK2 Tchem LIM domain kinase 2 0 Activities

Discover Target: LIMK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA4 Tchem Ribosomal protein S6 kinase alpha-4 0 Activities

Discover Target: RPS6KA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide
INCHI	InChI=1S/C20H25FN4O2/c1-14-13-24(19-7-8-22-12-18(19)21)9-10-25(14)20(26)23-15(2)16-5-4-6-17(11-16)27-3/h4-8,11-12,14-15H,9-10,13H2,1-3H3,(H,23,26)/t14-,15-/m1/s1
InChi Key	CIPXFTLGPVQJKN-HUUCEWRRSA-N
Canonical SMILES	Fc1cnccc1N1C[C@H](N(CC1)C(=O)N[C@H](C)c1cc(ccc1)OC)C
Isomeric SMILES	C[C@@H]1CN(CCN1C(=O)N[C@H](C)C2=CC(=CC=C2)OC)C3=C(C=NC=C3)F
PubChem CID	155749520

References

1. Ladduwahetty T, Lee MR, Maillard MC, Cachope R, Todd D, Barnes M, Beaumont V, Chauhan A, Gallati C, Haughan AF et al.. (2022) Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.. J Med Chem, 129 (3): (589-97). [PMID:35816678]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.