(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine is a selective antagonist of group II metabotropic glutamate receptor (mGluR). It has also been found to be a selective antagonist for presynaptic EAA receptors that are activated by (1S,3S)-ACPD and L-CCG-I. (2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine has been shown to enhance dorsal root-evoked excitatory synaptic transmission, indicating that metabotropic glutamate receptors in the spinal cord play a possibly physiological role.
