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3-[(2Z)-2-[5-(difluoromethyl)-1,2-dihydrothieno[3,2-c]pyrazol-3-ylidene]indol-6-yl]pentan-3-ol , CAS No.Z609425, Inhibitor of IL2 inducible T cell kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase

  • Moligand™
Item Number
Z609425
Grouped product items
SKUSizeAvailabilityPrice Qty
Z609425-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
Z609425-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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IL2 inducible T cell kinase Inhibitor LCK proto-oncogene，Src family tyrosine kinase Inhibitor spleen associated tyrosine kinase Inhibitor TXK tyrosine kinase Inhibitor

Basic Description

Synonymsthienopyrazolylindole inhibitor 477;compound 7
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of IL2 inducible T cell kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase

Associated Targets

TXK Tchem Tyrosine-protein kinase TXK 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ITK Tclin Tyrosine-protein kinase ITK/TSK 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SYK Tclin Tyrosine-protein kinase SYK 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[(2Z)-2-[5-(difluoromethyl)-1,2-dihydrothieno[3,2-c]pyrazol-3-ylidene]indol-6-yl]pentan-3-ol
INCHI InChI=1S/C19H19F2N3OS/c1-3-19(25,4-2)11-6-5-10-7-13(22-12(10)8-11)16-17-14(23-24-16)9-15(26-17)18(20)21/h5-9,18,22,25H,3-4H2,1-2H3,(H,23,24)
InChi Key CQZZZUNOWZUNNG-UHFFFAOYSA-N
Canonical SMILES CCC(c1ccc2c(c1)[nH]c(c2)c1n[nH]c2c1sc(c2)C(F)F)(CC)O
Isomeric SMILES CCC(CC)(C1=CC2=C(C=C1)C=C(N2)C3=NNC4=C3SC(=C4)C(F)F)O
PubChem CID 135566612

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Related Documents

 SDS

 Specification Sheet

References

1. McLean LR, Zhang Y, Zaidi N, Bi X, Wang R, Dharanipragada R, Jurcak JG, Gillespy TA, Zhao Z, Musick KY et al..  (2012)  X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase..  Bioorg Med Chem Lett,  22  (9): (3296-300).  [PMID:22464456]

Solution Calculators

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