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3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzenesulfonamide , CAS No.H608970, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase

Moligand™

PubChem CID: 23657507

Item Number

H608970

Grouped product items
SKU	Size	Availability	Price	Qty
H608970-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
H608970-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

LCK proto-oncogene，Src family tyrosine kinase Inhibitor LYN proto-oncogene，Src family tyrosine kinase Inhibitor spleen associated tyrosine kinase Inhibitor TXK tyrosine kinase Inhibitor

Basic Description

Synonyms	compound 23
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase

Associated Targets

TXK Tchem Tyrosine-protein kinase TXK 2 Activities

Discover Target: TXK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SYK Tclin Tyrosine-protein kinase SYK 2 Activities

Discover Target: SYK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck 1 Activities

Discover Target: LCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LYN Tclin Tyrosine-protein kinase Lyn 2 Activities

Discover Target: LYN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzenesulfonamide
INCHI	InChI=1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)
InChi Key	LKLIRPMEYRVLFV-UHFFFAOYSA-N
Canonical SMILES	Oc1ccc(c(c1)Nc1ccnc(n1)Nc1cccc(c1)S(=O)(=O)N)C
Isomeric SMILES	CC1=C(C=C(C=C1)O)NC2=NC(=NC=C2)NC3=CC(=CC=C3)S(=O)(=O)N
PubChem CID	23657507

PubChem CID

23657507

ChEMBL Ligand

CHEMBL249317

BindingDB Ligand

26166

References

1. Bamborough P, Angell RM, Bhamra I, Brown D, Bull J, Christopher JA, Cooper AW, Fazal LH, Giordano I, Hind L et al.. (2007) N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.. Bioorg Med Chem Lett, 17 (15): (4363-8). [PMID:17600705]

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