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3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid , CAS No.C608631, Inhibitor of Malonyl-CoA decarboxylase

3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid , CAS No.C608631, Inhibitor of Malonyl-CoA decarboxylase

Item Number

C608631

Grouped product items
SKU	Size	Availability	Price	Qty
C608631-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608631-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 10h
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Malonyl-CoA decarboxylase

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
INCHI	InChI=1S/C19H17F6N3O4S/c20-18(21,22)17(32,19(23,24)25)12-9-27-15(33-12)28-6-4-16(5-7-28,14(26)31)11-3-1-2-10(8-11)13(29)30/h1-3,8-9,32H,4-7H2,(H2,26,31)(H,29,30)
InChi Key	WNFAQVLTRONMFD-UHFFFAOYSA-N
Canonical SMILES	NC(=O)C1(CCN(CC1)c1ncc(s1)C(C(F)(F)F)(C(F)(F)F)O)c1cccc(c1)C(=O)O
Isomeric SMILES	C1CN(CCC1(C2=CC=CC(=C2)C(=O)O)C(=O)N)C3=NC=C(S3)C(C(F)(F)F)(C(F)(F)F)O
PubChem CID	52944985

PubChem CID	52944985
ChEMBL Ligand	CHEMBL1258253

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1. Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA et al.. (2010) Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.. Bioorg Med Chem Lett, 20 (20): (6088-92). [PMID:20832306]

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