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Home Applications Targets Kinases Other protein kinases 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[5,4-d]pyrazole-5-carboxamide , CAS No.M609148, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of aurora kinase C;Inhibitor of serine/threonine kinase 4
3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[5,4-d]pyrazole-5-carboxamide , CAS No.M609148, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of aurora kinase C;Inhibitor of serine/threonine kinase 4
Basic Description Synonyms compound 38 Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of aurora kinase C;Inhibitor of serine/threonine kinase 4
Names and Identifiers IUPAC Name 3-[(4-morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[5,4-d]pyrazole-5-carboxamide INCHI InChI=1S/C29H32N6O3S/c36-28(21-8-10-22(11-9-21)35-14-16-38-17-15-35)31-27-26-23(32-33-27)18-25(39-26)29(37)30-24(19-34-12-4-5-13-34)20-6-2-1-3-7-20/h1-3,6-11,18,24H,4-5,12-17,19H2,(H,30,37)(H2,31,32,33,36)/t24-/m1/s1 InChi Key ORWIYCURPDKSBI-XMMPIXPASA-N Canonical SMILES O=C(c1ccc(cc1)N1CCOCC1)Nc1n[nH]c2c1sc(c2)C(=O)N[C@@H](c1ccccc1)CN1CCCC1 Isomeric SMILES C1CCN(C1)C[C@H](C2=CC=CC=C2)NC(=O)C3=CC4=C(S3)C(=NN4)NC(=O)C5=CC=C(C=C5)N6CCOCC6 PubChem CID 11847343
References 1. Bindi S, Fancelli D, Alli C, Berta D, Bertrand JA, Cameron AD, Cappella P, Carpinelli P, Cervi G, Croci V et al. . (2010) Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.. Bioorg Med Chem, 18 (19): (7113-20). [PMID:20817473 ]
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