Grouped product items

SKU

Size

Availability

Price

Qty

D117084-5g

In stock

$19.90

D117084-25g

25g

In stock

$56.90

D117084-100g

100g

In stock

$201.90

Basic Description

Synonyms	3,5-Diiodo-L-tyrosine\|300-39-0\|Diiodotyrosine\|L-3,5-Diiodotyrosine\|L-Diiodotyrosine\|3,5-DIIODOTYROSINE\|(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid\|(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid\|H-Tyr(3,5-I2)-OH\|L-Tyrosine, 3,5-diio
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Substrate for the assay of halogenated tyrosine and thyroid hormone aminotransferase.Intermediate in the biosynthesis and alternative pathways of metabolism of thyroid hormones.

Associated Targets

ERG Tbio Transcriptional regulator ERG 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EYA2 Tbio Eyes absent homolog 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLH Tchem DNA polymerase eta 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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FEN1 Tchem Flap endonuclease 1 0 Activities

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KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities

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POLK Tbio DNA polymerase kappa 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS12 Tbio Regulator of G-protein signaling 12 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

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GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
INCHI	InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1
InChi Key	NYPYHUZRZVSYKL-ZETCQYMHSA-N
Canonical SMILES	C1=C(C=C(C(=C1I)O)I)CC(C(=O)O)N
Isomeric SMILES	C1=C(C=C(C(=C1I)O)I)C[C@@H](C(=O)O)N
WGK Germany	3
PubChem CID	9305
Molecular Weight	432.98
Reaxy-Rn	2218691

Database links

PubChem CID	9305
ChEBI	CHEBI:15768
CAS Registry No.	300-39-0
ChEMBL Ligand	CHEMBL1236469
Wikipedia	Diiodotyrosine
RCSB PDB Ligand	TYI
DrugCentral Ligand	3146

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot Number	Certificate Type	Date	Item
I2227172	Certificate of Analysis	Jul 17, 2024	D117084
I2227180	Certificate of Analysis	Jul 17, 2024	D117084
I2227183	Certificate of Analysis	Jul 17, 2024	D117084
K2126207	Certificate of Analysis	Sep 13, 2023	D117084
K2126208	Certificate of Analysis	Sep 13, 2023	D117084
G2007131	Certificate of Analysis	May 11, 2022	D117084
G2007130	Certificate of Analysis	May 11, 2022	D117084

Chemical and Physical Properties

Sensitivity	Moisture sensitive.
Specific Rotation[α]	1.2 ° (C=5, 1mol/L HCl)
Melt Point(°C)	200°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	2218691

References

1. A Balsam,F Sexton,M Borges,S H Ingbar. (1983-10-01) Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.. The Journal of clinical investigation, 72 ((4)): (1234-1245). [PMID:6630509]
2. Sangeeta Kumari,Sripadi Prabhakar,Mariappanadar Vairamani,Chebrolu Lavanya Devi,Gunturu Krishna Chaitanya,Kotamarthi Bhanuprakash. (2007-06-26) Chiral discrimination of D- and L-amino acids using iodinated tyrosines as chiral references: effect of iodine substituent.. Journal of the American Society for Mass Spectrometry, 18 ((8)): (1516-1524). [PMID:17588770]
3. M Nakano. (1967-01-10) Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria.. The Journal of biological chemistry, 242 ((1)): (73-81). [PMID:4381052]
4. Jana Frýdlová,Zdenka Kucerová,Marie Tichá. (2008-02-08) Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863 ((1)): (135-140). [PMID:18255363]
5. Yining Zheng,Yang Sun,Jicun Ren. (2008-10-31) Identification and quantitation of iodotyrosines and iodothyronines in hydrolysate of iodinated casein by capillary electrophoresis.. Talanta, 69 ((1)): (107-112). [PMID:18970540]

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3,5-Diiodo-L-tyrosine - 97%, high purity , CAS No.300-39-0

Basic Description

Associated Targets

ERG Tbio Transcriptional regulator ERG 0 Activities

EYA2 Tbio Eyes absent homolog 2 0 Activities

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

CBX1 Tbio Chromobox protein homolog 1 0 Activities

GMNN Tbio Geminin 0 Activities

POLH Tchem DNA polymerase eta 0 Activities

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

VDR Tclin Vitamin D3 receptor 0 Activities

FEN1 Tchem Flap endonuclease 1 0 Activities

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities

POLK Tbio DNA polymerase kappa 0 Activities

POLI Tchem DNA polymerase iota 0 Activities

RGS12 Tbio Regulator of G-protein signaling 12 0 Activities

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

MAPT Tclin Microtubule-associated protein tau 0 Activities

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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