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3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[2,1-e]pyrazol-3-yl)benzimidazol-1-yl]propan-1-ol , CAS No.P608741, Inhibitor of transforming growth factor beta receptor 1;Inhibitor of transforming growth factor beta receptor 2;Inhibitor of ZAK sterile alpha motif and leucine zipper containing kinase AZK

  • Moligand™
Item Number
P608741
Grouped product items
SKUSizeAvailabilityPrice Qty
P608741-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,000.90
P608741-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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transforming growth factor beta receptor 1 Inhibitor transforming growth factor beta receptor 2 Inhibitor ZAK sterile alpha motif and leucine zipper containing kinase AZK Inhibitor

Basic Description

Synonymscompound 15b
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of transforming growth factor beta receptor 1;Inhibitor of transforming growth factor beta receptor 2;Inhibitor of ZAK sterile alpha motif and leucine zipper containing kinase AZK

Associated Targets

TGFBR1 Tchem TGF-beta receptor type-1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TGFBR2 Tchem TGF-beta receptor type-2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP3K20 Tchem Mitogen-activated protein kinase kinase kinase 20 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[2,1-e]pyrazol-3-yl)benzimidazol-1-yl]propan-1-ol
INCHI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2
InChi Key SYCWRTUPLPDKDX-UHFFFAOYSA-N
Canonical SMILES OCCCn1cnc2c1cc(cc2)c1c2CCCn2nc1c1ccccn1
Isomeric SMILES C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=CC5=C(C=C4)N=CN5CCCO
PubChem CID 10361101

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Li HY, Wang Y, Heap CR, King CH, Mundla SR, Voss M, Clawson DK, Yan L, Campbell RM, Anderson BD et al..  (2006)  Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7..  J Med Chem,  49  (6): (2138-42).  [PMID:16539403]

Solution Calculators

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