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3-[6-[3-(hydroxymethyl)-2-phenylmorpholine-4-carbonyl]-1-methylbenzimidazol-2-yl]-1H-indole-6-carbonitrile , CAS No.H609198, Inhibitor of phosphodiesterase 12

3-[6-[3-(hydroxymethyl)-2-phenylmorpholine-4-carbonyl]-1-methylbenzimidazol-2-yl]-1H-indole-6-carbonitrile , CAS No.H609198, Inhibitor of phosphodiesterase 12

Item Number

H609198

Grouped product items
SKU	Size	Availability	Price	Qty
H609198-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$592.90
H609198-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,808.90

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Basic Description

Synonyms	GSK3036342A;PDE12-IN-3;compound 3
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphodiesterase 12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	3-[6-[3-(hydroxymethyl)-2-phenylmorpholine-4-carbonyl]-1-methylbenzimidazol-2-yl]-1H-indole-6-carbonitrile
INCHI	InChI=1S/C29H25N5O3/c1-33-25-14-20(29(36)34-11-12-37-27(26(34)17-35)19-5-3-2-4-6-19)8-10-23(25)32-28(33)22-16-31-24-13-18(15-30)7-9-21(22)24/h2-10,13-14,16,26-27,31,35H,11-12,17H2,1H3
InChi Key	BFUYKHPXWBXKQQ-UHFFFAOYSA-N
Canonical SMILES	Cn1c2c(ccc(c2)C(=O)N2CCOC(C2CO)c2ccccc2)nc1c1c[nH]c2cc(ccc12)C#N
PubChem CID	138454777

PubChem CID	138454777
RCSB PDB Ligand	4LC

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1. Wood ER, Bledsoe R, Chai J, Daka P, Deng H, Ding Y, Harris-Gurley S, Kryn LH, Nartey E, Nichols J et al.. (2015) The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.. J Biol Chem, 290 (32): (19681-96). [PMID:26055709]

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