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3-AP - 98% (HPLC), high purity , CAS No.143621-35-6

≥98%(HPLC)

CAS#: 143621-35-6
Formula: C₇H₉N₅S
Molecular Weight: 195.24
MDL number: MFCD00924747
PubChem CID: 9571836

Item Number

A167286

Grouped product items
SKU	Size	Availability	Price
A167286-5mg	5mg	In stock	$64.90
A167286-10mg	10mg	In stock	$84.90
A167286-25mg	25mg	In stock	$188.90
A167286-100mg	100mg	In stock	$680.90

Ribonucleotide reductase inhibitor; also an iron chelator

View related series

Nucleoside nucleotide oligonucleotide

Basic Description

Synonyms	Triapine\|236392-56-6\|143621-35-6\|200933-27-3\|3-AP\|3-Aminopyridine-2-carboxaldehyde thiosemicarbazone\|OCX 191\|2-((3-Aminopyridin-2-yl)methylene)hydrazinecarbothioamide\|PAN-811\|NSC-663249\|U4XIL4091C\|OCX-191\|OCX-0191\|[(E)-(3-aminopyridin-2-yl)methylideneamin
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy withcisplatin. Activein vivo. 3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC50 value of 0.3μM. It exhibits anti-proliferative a
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RRM2 Tclin Ribonucleoside-diphosphate reductase subunit M2 1 Activities

Discover Target: RRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 1 Activities

Discover Target: CISD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(E)-(3-aminopyridin-2-yl)methylideneamino]thiourea
INCHI	InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
InChi Key	XMYKNCNAZKMVQN-NYYWCZLTSA-N
Canonical SMILES	C1=CC(=C(N=C1)C=NNC(=S)N)N
Isomeric SMILES	C1=CC(=C(N=C1)/C=N/NC(=S)N)N
WGK Germany	3
PubChem CID	9571836
Molecular Weight	195.24

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
A2218092	Certificate of Analysis	Dec 07, 2021	A167286
A2218104	Certificate of Analysis	Dec 07, 2021	A167286
A2218209	Certificate of Analysis	Dec 07, 2021	A167286
A2218214	Certificate of Analysis	Dec 07, 2021	A167286

Solubility

Solvent:DMSO, Max Conc. mg/mL: 19.52, Max Conc. mM: 100

Sensitivity

Heat Sensitive

Melt Point(°C)

234 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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