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3β-hydroxydihydrocostunolide , CAS No.31560-72-2, Antagonist of TAS2R46

Item Number

H607152

Grouped product items
SKU	Size	Availability	Price	Qty
H607152-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$942.90
H607152-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,000.90

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Basic Description

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(3R,3aS,6Z,9S,10Z,11aS)-9-hydroxy-3,6,10-trimethyl-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-2-one
INCHI	InChI=1S/C15H22O3/c1-9-4-6-12-11(3)15(17)18-14(12)8-10(2)13(16)7-5-9/h5,8,11-14,16H,4,6-7H2,1-3H3/b9-5-,10-8-/t11-,12+,13+,14-/m1/s1
InChi Key	RLHPCSSGTQNSJN-DCOVWINISA-N
Canonical SMILES	C[C@@H]1[C@@H]2CC/C(=C\C[C@@H](/C(=C\[C@H]2OC1=O)/C)O)/C
Isomeric SMILES	C[C@@H]1[C@@H]2CC/C(=C\C[C@@H](/C(=C\[C@H]2OC1=O)/C)O)/C
PubChem CID	90471461

PubChem CID	90471461
CAS Registry No.	31560-72-2

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1. Brockhoff A, Behrens M, Roudnitzky N, Appendino G, Avonto C, Meyerhof W. (2011) Receptor agonism and antagonism of dietary bitter compounds.. J Neurosci, 31 (41): (14775-82). [PMID:21994393]
2. Talmon M, Rossi S, Lim D, Pollastro F, Palattella G, Ruffinatti FA, Marotta P, Boldorini R, Genazzani AA, Fresu LG. (2019) Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca²⁺-shuttling event.. J Biol Chem, 294 (33): (12472-12482). [PMID:31248983]

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