3β-OH , CAS No.O607153, Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Item Number

O607153

Grouped product items
SKU	Size	Availability	Price	Qty
O607153-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,190.90
O607153-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,334.90

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Synonyms

B260

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S,5R,10S,13S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carbonitrile
INCHI	InChI=1S/C20H31NO/c1-19-9-7-15(22)11-13(19)3-5-16-17-6-4-14(12-21)20(17,2)10-8-18(16)19/h13-18,22H,3-11H2,1-2H3/t13-,14-,15+,16?,17?,18?,19+,20-/m1/s1
InChi Key	DVTDUTYENPZLFP-FXEFULGUSA-N
Canonical SMILES	N#C[C@H]1CCC2[C@]1(C)CCC1C2CC[C@H]2[C@]1(C)CC[C@@H](C2)O
PubChem CID	129257213

References

1. Wang M, He Y, Eisenman LN, Fields C, Zeng CM, Mathews J, Benz A, Fu T, Zorumski E, Steinbach JH et al.. (2002) 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.. J Neurosci, 22 (9): (3366-75). [PMID:11978813]
2. Joksovic PM, Covey DF, Todorovic SM. (2007) Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid.. Ann N Y Acad Sci, 1122 (3): (83-94). [PMID:18077566]
3. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. (2004) 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.. Mol Pharmacol, 66 (5): (1223-35). [PMID:15280444]
4. Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. (2018) A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.. Br J Anaesth, 120 (4): (768-778). [PMID:29576117]

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Basic Description