3CAI - 95% (HPLC), high purity , CAS No.28755-03-5

Item Number

C169278

• Synonyms: 28755-03-5|3CAI|2-Chloro-1-(1H-indol-3-yl)ethanone|3-Chloroacetylindole|2-Chloro-1-(1H-indol-3-yl)-ethanone|Ethanone, 2-chloro-1-(1H-indol-3-yl)-|2-chloro-1-(1H-indol-3-yl)ethan-1-one|3-[(chloro)acetyl]-indole|3-(Chloroacetyl)-1H-indole|SCHEMBL3717752|DTX
• Specifications & Purity: 95% (HPLC)
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

product describtion:

A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50<1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.