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AGC:Containing PKA, PKG, PKC families
(3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide , CAS No.S609112, Inhibitor of Protein kinase G (PKG) 2;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 2

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(3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide , CAS No.S609112, Inhibitor of Protein kinase G (PKG) 2;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Moligand™

PubChem CID: 46871820

Item Number

S609112

Grouped product items
SKU	Size	Availability	Price	Qty
S609112-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
S609112-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

Protein kinase G (PKG) 2 Inhibitor protein kinase N2 Inhibitor Rho associated coiled-coil containing protein kinase 2 Inhibitor

Basic Description

Synonyms	compound 32
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Protein kinase G (PKG) 2;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Associated Targets

CDC42 Tchem Cell division control protein 42 homolog 1 Activities

Discover Target: CDC42

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK2 Tclin Rho-associated protein kinase 2 2 Activities

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKN2 Tchem Serine/threonine-protein kinase N2 2 Activities

Discover Target: PKN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG2 Tchem cGMP-dependent protein kinase 2 2 Activities

Discover Target: PRKG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type 0 Activities

Discover Target: PRKCE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide
INCHI	InChI=1S/C20H17Cl2N3O2/c21-13-3-1-11(2-4-13)15-9-23-10-16(15)20(27)25-18-7-12-5-6-24-19(26)14(12)8-17(18)22/h1-8,15-16,23H,9-10H2,(H,24,26)(H,25,27)/t15-,16+/m0/s1
InChi Key	XBFAFSAUQFDEOK-JKSUJKDBSA-N
Canonical SMILES	O=C([C@@H]1CNC[C@H]1c1ccc(cc1)Cl)Nc1cc2cc[nH]c(=O)c2cc1Cl
Isomeric SMILES	C1[C@H]([C@@H](CN1)C(=O)NC2=C(C=C3C(=C2)C=CNC3=O)Cl)C4=CC=C(C=C4)Cl
PubChem CID	46871820

Database links

ChEMBL Ligand	CHEMBL1082821
PubChem CID	46871820

Certificates

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References

1. Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER. (2010) Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.. Bioorg Med Chem Lett, 20 (12): (3746-9). [PMID:20471253]

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