(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride - 95%, high purity , CAS No.1345866-68-3

Item Number

T467095

Grouped product items
SKU	Size	Availability	Price	Qty
T467095-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$149.90
T467095-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$319.90

Basic Description

Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine is a 1,2,4,5-tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications.Amine functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.

Names and Identifiers

IUPAC Name	[4-(1,2,4,5-tetrazin-3-yl)phenyl]methanamine
INCHI	InChI=1S/C9H9N5/c10-5-7-1-3-8(4-2-7)9-13-11-6-12-14-9/h1-4,6H,5,10H2
InChi Key	JGCOJRPYFRRONJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1CN)C2=NN=CN=N2
Isomeric SMILES	C1=CC(=CC=C1CN)C2=NN=CN=N2
PubChem CID	58490200
UN Number	2811
Molecular Weight	187.2

Flash Point(°F)

Not applicable

Flash Point(°C)

Not applicable

Melt Point(°C)

206-225℃ (de

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
Class	6.1
RIDADR	UN 2811 6.1 / PGIII

References

1. Melissa L Blackman,Maksim Royzen,Joseph M Fox. (2008-09-19) Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.. Journal of the American Chemical Society, 130 ((41)): (13518-13519). [PMID:18798613]
2. Neal K Devaraj,Ralph Weissleder,Scott A Hilderbrand. (2008-12-05) Tetrazine-based cycloadditions: application to pretargeted live cell imaging.. Bioconjugate chemistry, 19 ((12)): (2297-2299). [PMID:19053305]
3. Mark R Karver, Ralph Weissleder, Scott A Hilderbrand,. (2011-09-29) Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.. Bioconjugate chemistry, 22 ((11)): ( 2263-2270 ). [PMID:21950520]

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Basic Description