4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
1.Jiaqi Qiu, Siyuan Xiang, Miyao Sun, Mingqian Tan. (2023) Preparation of Polysaccharide–Protein Hydrogels with an Ultrafast Self-Healing Property as a Superior Oral Delivery System of Probiotics. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (15):[PMID:37978937][10.1021/acs.jafc.3c05898]
5.Xuedi Zhang, Xue Zhao, Zheng Hua, Shanghua Xing, Jiaxuan Li, Siyuan Fei, Mingqian Tan. (2023) ROS-triggered self-disintegrating and pH-responsive astaxanthin nanoparticles for regulating the intestinal barrier and colitis. BIOMATERIALS, 292 (121937). [PMID:36495803][10.1016/j.biomaterials.2022.121937]
6.Luo Zhenyu, Luo Lihua, Lu Yichao, Zhu Chunqi, Qin Bing, Jiang Mengshi, Li Xiang, Shi Yingying, Zhang Junlei, Liu Yu, Shan Xinyu, Yin Hang, Guan Guannan, Du Yongzhong, Cheng Ningtao, You Jian. (2022) Dual-binding nanoparticles improve the killing effect of T cells on solid tumor. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1):(1-13). [PMID:35672752][10.1186/s12951-022-01480-z]
7.Wen Liu, Jian Dai, Wei Xue. (2018) Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform. Journal of Materials Chemistry B, 6 (42):(6817-6830). [PMID:32254698][10.1039/C8TB01791C]
References
1.Jiaqi Qiu, Siyuan Xiang, Miyao Sun, Mingqian Tan. (2023) Preparation of Polysaccharide–Protein Hydrogels with an Ultrafast Self-Healing Property as a Superior Oral Delivery System of Probiotics. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (15):[PMID:37978937][10.1021/acs.jafc.3c05898]
5.Xuedi Zhang, Xue Zhao, Zheng Hua, Shanghua Xing, Jiaxuan Li, Siyuan Fei, Mingqian Tan. (2023) ROS-triggered self-disintegrating and pH-responsive astaxanthin nanoparticles for regulating the intestinal barrier and colitis. BIOMATERIALS, 292 (121937). [PMID:36495803][10.1016/j.biomaterials.2022.121937]
6.Luo Zhenyu, Luo Lihua, Lu Yichao, Zhu Chunqi, Qin Bing, Jiang Mengshi, Li Xiang, Shi Yingying, Zhang Junlei, Liu Yu, Shan Xinyu, Yin Hang, Guan Guannan, Du Yongzhong, Cheng Ningtao, You Jian. (2022) Dual-binding nanoparticles improve the killing effect of T cells on solid tumor. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1):(1-13). [PMID:35672752][10.1186/s12951-022-01480-z]
7.Wen Liu, Jian Dai, Wei Xue. (2018) Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform. Journal of Materials Chemistry B, 6 (42):(6817-6830). [PMID:32254698][10.1039/C8TB01791C]
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