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Targets
G protein-coupled receptors (GPCRs)
Leukotriene receptors
4-(4-carboxybutyl)-8-(2-oxo-2-{4-[(6-phenylhexyl)oxy]phenyl}ethyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid , CAS No.C608743, Antagonist of CysLT 1 receptor;Antagonist of CysLT 2 receptor

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4-(4-carboxybutyl)-8-(2-oxo-2-{4-[(6-phenylhexyl)oxy]phenyl}ethyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid , CAS No.C608743, Antagonist of CysLT 1 receptor;Antagonist of CysLT 2 receptor

Moligand™

PubChem CID: 145996521

Item Number

C608743

Grouped product items
SKU	Size	Availability	Price	Qty
C608743-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608743-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

CysLT1 receptor Antagonist CysLT2 receptor Antagonist

Basic Description

Synonyms	compound 15b
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CysLT 1 receptor;Antagonist of CysLT 2 receptor

Associated Targets

CYSLTR2 Tchem Cysteinyl leukotriene receptor 2 0 Activities

Discover Target: CYSLTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 0 Activities

Discover Target: CYSLTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-(4-carboxybutyl)-8-(2-oxo-2-{4-[(6-phenylhexyl)oxy]phenyl}ethyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
INCHI	InChI=1S/C34H39NO7/c36-30(26-17-19-28(20-18-26)41-22-9-2-1-4-11-25-12-5-3-6-13-25)23-27-14-10-15-29-33(27)42-31(34(39)40)24-35(29)21-8-7-16-32(37)38/h3,5-6,10,12-15,17-20,31H,1-2,4,7-9,11,16,21-24H2,(H,37,38)(H,39,40)
InChi Key	HEZMXOWAEONYPI-UHFFFAOYSA-N
Canonical SMILES	OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O
PubChem CID	145996521

Database links

GPCRdb Ligand	compound 15b [PMID: 31811124]
PubChem CID	145996521

Certificates

Certificate of Analysis(COA)

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References

1. Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T et al.. (2019) Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.. Nat Commun, 10 (1): (5573). [PMID:31811124]

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