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4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide , CAS No.B609392, Inhibitor of AP2 associated kinase 1;Inhibitor of BMP2 inducible kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of TANK binding kinase 1;Inhibitor of tyrosine kinase 2

  • Moligand™
Item Number
B609392
Grouped product items
SKUSizeAvailabilityPrice Qty
B609392-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$700.90
B609392-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
AP2 associated kinase 1 Inhibitor BMP2 inducible kinase Inhibitor serine/threonine kinase 16 Inhibitor TANK binding kinase 1 Inhibitor tyrosine kinase 2 Inhibitor

Basic Description

Synonymscompound 6
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of AP2 associated kinase 1;Inhibitor of BMP2 inducible kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of TANK binding kinase 1;Inhibitor of tyrosine kinase 2

Associated Targets

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK2A2 Tchem Casein kinase II subunit alpha' 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK2A1 Tchem Casein kinase II subunit alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRPF4B Tchem Serine/threonine-protein kinase PRP4 homolog 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK17A Tchem Serine/threonine-protein kinase 17A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK16 Tchem Serine/threonine-protein kinase 16 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIP5K1A Tbio Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BMP2K Tchem BMP-2-inducible protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKB Tchem Aurora kinase B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ULK3 Tchem Serine/threonine-protein kinase ULK3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NUAK1 Tchem NUAK family SNF1-like kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
INCHI InChI=1S/C22H25BrN6O3S/c23-20-14-26-22(27-18-3-1-2-17(12-18)15-29-8-10-32-11-9-29)28-21(20)25-13-16-4-6-19(7-5-16)33(24,30)31/h1-7,12,14H,8-11,13,15H2,(H2,24,30,31)(H2,25,26,27,28)
InChi Key RDROKTFULACVDQ-UHFFFAOYSA-N
Canonical SMILES NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1
Isomeric SMILES C1COCCN1CC2=CC(=CC=C2)NC3=NC=C(C(=N3)NCC4=CC=C(C=C4)S(=O)(=O)N)Br
PubChem CID 145900912

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD.  (2022)  Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration..  J Med Chem,  65  (2): (1313-1328).  [PMID:34333981]

Solution Calculators

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