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4-Amino-5-fluoro-8-(5-methoxy-1H-indazol-6-yl)quinoline-3-carboxamide , CAS No.A608998, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of IL2 inducible T cell kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kin

Moligand™

PubChem CID: 139030520

Item Number

A608998

Grouped product items
SKU	Size	Availability	Price	Qty
A608998-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A608998-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

BLK proto-oncogene，Src family tyrosine kinase Inhibitor Bruton tyrosine kinase Inhibitor FYN proto-oncogene，Src family tyrosine kinase Inhibitor IL2 inducible T cell kinase Inhibitor SRC proto-oncogene，non-receptor tyrosine kinase Inhibitor tec protein tyrosine kinase Inhibitor

Basic Description

Synonyms	compound 25
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of IL2 inducible T cell kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kin

Associated Targets

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

Discover Target: SRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

Discover Target: YES1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FYN Tclin Tyrosine-protein kinase Fyn 0 Activities

Discover Target: FYN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITK Tclin Tyrosine-protein kinase ITK/TSK 0 Activities

Discover Target: ITK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TEC Tchem Tyrosine-protein kinase Tec 0 Activities

Discover Target: TEC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 1 Activities

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLK Tchem Tyrosine-protein kinase Blk 0 Activities

Discover Target: BLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-Amino-5-fluoro-8-(5-methoxy-1H-indazol-6-yl)quinoline-3-carboxamide
INCHI	InChI=1S/C18H14FN5O2/c1-26-14-4-8-6-23-24-13(8)5-10(14)9-2-3-12(19)15-16(20)11(18(21)25)7-22-17(9)15/h2-7H,1H3,(H2,20,22)(H2,21,25)(H,23,24)
InChi Key	RFCJOYPMBVRHBV-UHFFFAOYSA-N
Canonical SMILES	COc1cc2cn[nH]c2cc1c1ccc(c2c1ncc(c2N)C(=O)N)F
Isomeric SMILES	COC1=C(C=C2C(=C1)C=NN2)C3=C4C(=C(C=C3)F)C(=C(C=N4)C(=O)N)N
PubChem CID	139030520

References

1. Smith CR, Dougan DR, Komandla M, Kanouni T, Knight B, Lawson JD, Sabat M, Taylor ER, Vu P, Wyrick C. (2015) Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase.. J Med Chem, 58 (14): (5437-44). [PMID:26087137]
2. Yao X, Sun X, Jin S, Yang L, Xu H, Rao Y. (2019) Discovery of 4-Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton's Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis.. J Med Chem, 62 (14): (6561-6574). [PMID:31260299]

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