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4-Methyl-2-(1-piperidinyl)-quinoline - ≥98% (HPLC), high purity , CAS No.5465-86-1, Channel blocker of TRPC4;Channel blocker of TRPC5

Moligand™
≥98%(HPLC)

CAS#: 5465-86-1
Formula: C₁₅H₁₈N₂
Molecular Weight: 226.32
MDL number: MFCD00817920
PubChem CID: 230710

Item Number

M134489

Grouped product items
SKU	Size	Availability	Price
M134489-5mg	5mg	In stock	$53.90
M134489-25mg	25mg	In stock	$243.90
M134489-100mg	100mg	In stock	$303.90

Selective TRPC4 blocker

View related series

TRPC4 Channel blocker TRPC5 Channel blocker

Basic Description

Synonyms	5465-86-1\|ML204\|4-methyl-2-(piperidin-1-yl)quinoline\|ML 204\|4-methyl-2-piperidin-1-ylquinoline\|4-Methyl-2-(1-piperidinyl)-quinoline\|4-Methyl-2-(1-piperidinyl)quinoline\|5465-86-1 (free base)\|ML-204\|VU0024172-3\|NSC25850\|Cambridge id 5563912\|MLS001007138\|4-m
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Blocker of TRPC4 channels (IC50values are 0.96 and 2.6μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPC4;Channel blocker of TRPC5

Associated Targets

CBX1 Tbio Chromobox protein homolog 1 0 Activities

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC4 Tchem Short transient receptor potential channel 4 2 Activities

Discover Target: TRPC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 1 Activities

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC6 Tchem Short transient receptor potential channel 6 0 Activities

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 0 Activities

Discover Target: L3MBTL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GAA Tclin Lysosomal alpha-glucosidase 0 Activities

Discover Target: GAA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMPD1 Tchem Sphingomyelin phosphodiesterase 0 Activities

Discover Target: SMPD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-methyl-2-piperidin-1-ylquinoline
INCHI	InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
InChi Key	USYRQXDHKXGTCK-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
Isomeric SMILES	CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
WGK Germany	3
PubChem CID	230710
Molecular Weight	226.32

PubChem CID

230710

CAS Registry No.

5465-86-1

ChEMBL Ligand

CHEMBL1459962

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
G2215686	Certificate of Analysis	Apr 07, 2024	M134489
G2215687	Certificate of Analysis	Apr 07, 2024	M134489
G2215688	Certificate of Analysis	Apr 07, 2024	M134489

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

References

1. Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P et al.. (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.. J Biol Chem, 286 (38): (33436-46). [PMID:21795696]
2. Miller MR, Shi J, Wu M, Engers J, Hopkins CR, Lindsley CW, Salovich JM, Zhu Y, Tian JB, Zhu MX et al.. (2010) Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program, 129 (3): (589-97). [PMID:22049577]

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