Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
O648808-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $150.90 | |
O648808-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $240.90 | |
O648808-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $480.90 | |
O648808-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $760.90 | |
O648808-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,200.90 |
Phenylpropanoids Lignans Phenols Monophenols
Synonyms | 4-O-Methylhonokiol|68592-15-4|4-O-Methyl honokiol|METHYLHONOKIOL|4-methoxyhonokiol|4'-O-Methylhonokiol|TUH6B83HJW|4'-METHOXY-3',5-DI-2-PROPENYL-(1,1'-BIPHENYL)-2-OL|CHEMBL89700|NSC-293101|[1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propenyl-|(1,1'-Biphenyl |
---|---|
Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. In Vitro 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues . 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Viscous liquid IC50& Target:PPARγ NF-κB |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol |
---|---|
INCHI | InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3 |
InChi Key | OQFHJKZVOALSPV-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C(C=C1)C2=C(C=CC(=C2)CC=C)O)CC=C |
Isomeric SMILES | COC1=C(C=C(C=C1)C2=C(C=CC(=C2)CC=C)O)CC=C |
Alternate CAS | 131845-16-4,68592-15-4 |
PubChem CID | 155160 |
NSC Number | 293101 |
MeSH Entry Terms | 4-O-methylhonokiol |
Molecular Weight | 280.36 |
Enter Lot Number to search for COA:
Solubility | DMSO : 100 mg/mL (356.68 mM; Need ultrasonic) |
---|