4-Thiouridine - 98%, high purity , CAS No.13957-31-8

Item Number

T122953

Grouped product items
SKU	Size	Availability	Price
T122953-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$23.90
T122953-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$79.90
T122953-100mg	100mg	In stock	$199.90
T122953-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$599.90

Ribonucleoside analog. Antisense agent. RNA synthesis inhibitor.

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Basic Description

Synonyms	1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-3,4-dihydropyrimidin-2(1H)-one \| 1-β-D-Ribofuranosyl-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone \| RNA synthesis inhibitor \| 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	4-Thiouridine is a photoreactive uridine analog. Application： 4-Thiouridine has been used in labeling and isolation of nascent RNAs.

Names and Identifiers

IUPAC Name	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
INCHI	InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChi Key	ZLOIGESWDJYCTF-XVFCMESISA-N
Canonical SMILES	C1=CN(C(=O)NC1=S)C2C(C(C(O2)CO)O)O
Isomeric SMILES	C1=CN(C(=O)NC1=S)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
WGK Germany	3
PubChem CID	3032615
Molecular Weight	260.27

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
G2430268	Certificate of Analysis	Jul 03, 2024	T122953
G2430269	Certificate of Analysis	Jul 03, 2024	T122953
G2430270	Certificate of Analysis	Jul 03, 2024	T122953
G2430271	Certificate of Analysis	Jul 03, 2024	T122953
G2430272	Certificate of Analysis	Jul 03, 2024	T122953
G2411159	Certificate of Analysis	Apr 27, 2024	T122953
G2411160	Certificate of Analysis	Apr 27, 2024	T122953
E1528024	Certificate of Analysis	Feb 08, 2023	T122953

Citations of This Product

1. Xiuying Lin, Qianhui Zhang, Yichao Qin, Qisheng Zhong, Daizhu Lv, Xiaopeng Wu, Pengcheng Fu, Huan Lin. (2022) Potential Misidentification of Natural Isomers and Mass-Analogs of Modified Nucleosides by Liquid Chromatography–Triple Quadrupole Mass Spectrometry. Genes, 13 (5): (878). [PMID:35627263] [10.3390/genes13050878]

References

1. Song J et al.. (2022) Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.. Nat Commun, 13 (7096). [PMID:36402769]
2. Fischer V et al.. (2021) The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms.. Cell Rep, 36 (8): (109598). [PMID:34433046]
3. Detilleux D et al.. (2022) The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells.. Elife, 11 [PMID:35244540]
4. Xiuying Lin, Qianhui Zhang, Yichao Qin, Qisheng Zhong, Daizhu Lv, Xiaopeng Wu, Pengcheng Fu, Huan Lin. (2022) Potential Misidentification of Natural Isomers and Mass-Analogs of Modified Nucleosides by Liquid Chromatography–Triple Quadrupole Mass Spectrometry. Genes, 13 (5): (878). [PMID:35627263] [10.3390/genes13050878]

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Basic Description