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5-(1-piperidin-4-ylpyrazol-4-yl)-3-(6-pyrrolidin-1-yl-1,3-benzoxazol-2-yl)pyridin-2-amine , CAS No.P608864, Inhibitor of beta adrenergic receptor kinase 1;Inhibitor of G protein-coupled receptor kinase 5;Inhibitor of MET proto-oncogene; receptor tyrosine kinase

  • Moligand™
Item Number
P608864
Grouped product items
SKUSizeAvailabilityPrice Qty
P608864-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,000.90
P608864-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
beta adrenergic receptor kinase 1 Inhibitor G protein-coupled receptor kinase 5 Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor

Basic Description

Synonymscompound 1o
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of beta adrenergic receptor kinase 1;Inhibitor of G protein-coupled receptor kinase 5;Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Associated Targets

MET Tclin Hepatocyte growth factor receptor 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALK Tclin ALK tyrosine kinase receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRK2 Tchem Beta-adrenergic receptor kinase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRK5 Tchem G protein-coupled receptor kinase 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(1-piperidin-4-ylpyrazol-4-yl)-3-(6-pyrrolidin-1-yl-1,3-benzoxazol-2-yl)pyridin-2-amine
INCHI InChI=1S/C24H27N7O/c25-23-20(24-29-21-4-3-19(12-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
InChi Key MWVKLRSIDOXBSE-UHFFFAOYSA-N
Canonical SMILES Nc1ncc(cc1c1nc2c(o1)cc(cc2)N1CCCC1)c1cnn(c1)C1CCNCC1
Isomeric SMILES C1CCN(C1)C2=CC3=C(C=C2)N=C(O3)C4=C(N=CC(=C4)C5=CN(N=C5)C6CCNCC6)N
PubChem CID 44256277

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Cho SY, Lee BH, Jung H, Yun CS, Ha JD, Kim HR, Chae CH, Lee JH, Seo HW, Oh KS.  (2013)  Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors..  Bioorg Med Chem Lett,  23  (24): (6711-6).  [PMID:24210504]

Solution Calculators

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