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5,7-Dichlorokynurenic acid - 97%, high purity , CAS No.131123-76-7, Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D;Antagonist of glycine receptor α2 subunit

  • Moligand™
  • ≥97%
Item Number
D274816
Grouped product items
SKUSizeAvailabilityPrice Qty
D274816-10mg
10mg
In stock
$83.90
D274816-50mg
50mg
In stock
$310.90
D274816-100mg
100mg
In stock
$559.90
D274816-500mg
500mg
In stock
$2,519.90

NMDA receptor glycine site antagonist

Basic Description

Synonyms5,7-Dichlorokynurenic acid|131123-76-7|5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID|5,7-Dcka|5,7-Dichloroquinurenic acid|5,7-Dichorokynurenic acid|5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid|2-Quinolinecarboxylic acid, 5,7-dichloro-4-hydroxy-|5
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPotent NMDA receptor glycine site antagonist.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D;Antagonist of glycine receptor α2 subunit
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLRA2 Tchem Glycine receptor subunit alpha-2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NGFR Tclin Tumor necrosis factor receptor superfamily member 16 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALB Tchem Serum albumin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ARSA Tbio Arylsulfatase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIK1 Tclin Glutamate receptor ionotropic, kainate 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIK2 Tclin Glutamate receptor ionotropic, kainate 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN3A Tclin Glutamate receptor ionotropic, NMDA 3A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488179640
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179640
IUPAC Name 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
INCHI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
InChi Key BGKFPRIGXAVYNX-UHFFFAOYSA-N
Canonical SMILES C1=C(C=C(C2=C1NC(=CC2=O)C(=O)O)Cl)Cl
Isomeric SMILES C1=C(C=C(C2=C1NC(=CC2=O)C(=O)O)Cl)Cl
Alternate CAS 131123-76-7,190908-40-8
PubChem CID 1779
MeSH Entry Terms 5,7-DCKA;5,7-dichlorokynurenic acid;5,7-dichloroquinurenic acid
Molecular Weight 258.06

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot NumberCertificate TypeDateItem
C2330624Certificate of AnalysisJan 15, 2024 D274816
C2330622Certificate of AnalysisJan 15, 2024 D274816
C2330621Certificate of AnalysisJan 15, 2024 D274816
C2330620Certificate of AnalysisJan 15, 2024 D274816
C2330613Certificate of AnalysisJan 12, 2024 D274816
C2330616Certificate of AnalysisJan 12, 2024 D274816
C2330619Certificate of AnalysisJan 12, 2024 D274816
C2330623Certificate of AnalysisJan 12, 2024 D274816

Chemical and Physical Properties

SolubilitySoluble in 1 eq. NaOH to 50 mM

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

Solution Calculators