[5-amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanone , CAS No.A609294, Inhibitor of cyclin dependent kinase 19;Inhibitor of cyclin dependent kinase 8
[5-amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanone , CAS No.A609294, Inhibitor of cyclin dependent kinase 19;Inhibitor of cyclin dependent kinase 8
1.Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S et al.. (2008) CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.. Nature, 455 (7212):(547-51). [PMID:18794900]
2.Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI et al.. (2010) The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.. Nature, 468 (7327):(1105-9). [PMID:21179167]
3.Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R et al.. (2016) 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.. ACS Med Chem Lett, 7 (6):(573-8). [PMID:27326329]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.